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Predictive Immune Modeling of Solid Tumors
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Predictive Immune Modeling of Solid Tumors

Published on: February 25, 2020

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The evolving landscape of immunotherapy in solid tumors

Jessica M Keilson1, Hannah M Knochelmann1,2,3, Chrystal M Paulos1,2

  • 1Division of Surgical Oncology, Department of Surgery, Winship Cancer Institute, Emory University, Atlanta, Georgia, USA.

Journal of Surgical Oncology
|February 17, 2021
PubMed

While surgical resection, local and cytotoxic therapies have long formed the basis of cancer care, immunotherapy now plays a key role in supplementing and even replacing these agents in the first line. Here we review the early success of programmed cell death protein 1 (PD-1) and cytotoxic T-lymphocyte associated protein 4 blockade and discuss biomarkers of therapeutic response. We next highlight a select group of novel targets in Phase III trials both as monotherapies and in combination with PD-1 inhibitors. Finally, we discuss innovations which seek to improve outcomes in therapy-resistant solid tumors.

Keywords:
cancerimmunotherapysolid tumorstumor immunology

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