Correction: Small-molecule-based human genome G4 profiling reveals potential gene regulation activity

Area of Science:

• Biochemistry
• Genomics
• Chemical Biology

Context:

• G-quadruplex (G4) structures are non-canonical DNA secondary structures found in the human genome.
• These structures are implicated in various biological processes, including gene regulation and replication.
• Small molecules are increasingly used to probe and interact with G4 structures.

Purpose:

• To correct and clarify the findings presented in the original publication regarding human genome G4 profiling.
• To refine the understanding of the gene regulation activity associated with G4 structures.
• To ensure accurate reporting of small-molecule interactions with G4s.

Summary:

• The correction pertains to the study "Small-molecule-based human genome G4 profiling reveals potential gene regulation activity."
• It addresses specific details or interpretations within the original research.
• The core finding relates to the identification of potential gene regulatory roles for G4 structures profiled using small molecules.

Impact:

• Ensures the scientific record is accurate for researchers studying G-quadruplexes.
• Facilitates a more precise understanding of G4 structure function in gene regulation.
• Supports the development of G4-targeting therapeutics and research tools.