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Differences in the gut microbiota between young and elderly persons in Korea
Seung Yun Lee1, Da Young Lee1, Hea Jin Kang1
1Department of Animal Science and Technology, Chung-Ang University, Anseong 17546, Republic of Korea.
Nutrition Research (New York, N.Y.)
|February 17, 2021
Summary
The gut microbiota composition significantly differs between young and elderly Koreans. This study highlights age-related variations in gut bacteria, impacting future research models.
Area of Science:
- Microbiology
- Human Health
- Aging Research
Background:
- Gut microbiota composition varies globally due to dietary differences.
- Understanding age-related gut microbiota changes is crucial for health and research.
Purpose of the Study:
- To investigate age-related differences in the gut microbiota of Koreans.
- To provide data for developing age-specific in vitro digestion models for Koreans.
Main Methods:
- Fecal samples collected from 100 young (20-25 years) and 100 elderly (over 65 years) Koreans.
- Gut microbiota composition analyzed using next-generation sequencing.
- Statistical analysis of taxonomic differences, focusing on major phyla and genera.
Main Results:
- Significant differences in gut microbiota taxonomic composition between young and elderly Koreans (P < 0.001).
- Elderly Koreans showed higher relative abundance of Escherichia, while young Koreans had higher Lactobacillus.
- Key phyla showing differences include Firmicutes, Proteobacteria, Tenericutes, and Fusobacteria.
Conclusions:
- Age is a significant factor influencing gut microbiota composition in the Korean population.
- Findings suggest distinct gut microbial profiles for young and elderly Koreans.
- Results can inform the development of more accurate, age-specific in vitro human digestion models.
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