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Emerging Molecular Functions of MicroRNA-9: Cancer Pathology and Therapeutic Implications
Behnam Emamgolizadeh Gurt Tapeh1, Bashir Mosayyebi2, Behzad Mansoori1
1Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Abstract:
MiRNAs that are characterized by small non-coding RNAs orchestrate the expression of important genes involved in cancer cell development processes, including apoptosis, proliferation, angiogenesis, metastasis, and drug resistance at the post-transcriptional level. Dysregulation of miR-9 in various cancers has been reported. Recently, miR-9 has been considered as a key miRNA in various malignancies. However, its importance in the pathogenesis of different neoplasms is not yet well defined. Accordingly, this study was conducted in order to clarify the potential roles of miR-9 in the development of various cancers, prognosis, and treatment approaches. We have shown that a large number of miR-9 targets play fundamental roles in carcinogenesis, and that is dysregulated in various cancer cells. Our findings werefound aberrant miR-9 expression in a majority of cancers. This review article generally emphasizesthe critical roles of miR-9 in cancer cell progression. Additionally, we intended to investigate the effects of down-regulation or up-regulation of miR-9 in different types of cancers. It is hoped that a good understanding of the regulatory roles of miR-9 in various cancers ishelpful for using miR-9 in clinical settings, including prognosis, diagnosis, and miRNA-based target therapy.
Insights
MicroRNAs (miRNAs), specifically miR-9, play a crucial role in cancer development by regulating gene expression. Aberrant miR-9 expression is linked to various cancers, impacting progression and treatment strategies.
Area of Science:
- Molecular Biology
- Genetics
- Oncology
Background:
- MicroRNAs (miRNAs) are small non-coding RNAs regulating gene expression post-transcriptionally.
- Dysregulation of miR-9 has been observed in numerous cancers, affecting key cellular processes.
- The precise role of miR-9 in neoplasm pathogenesis requires further elucidation.
Purpose of the Study:
- To clarify the multifaceted roles of miR-9 in cancer development.
- To investigate the impact of miR-9 dysregulation on cancer prognosis and therapeutic strategies.
- To review the significance of miR-9 in various malignancies.
Main Methods:
- Literature review focusing on miR-9's function in cancer.
- Analysis of miR-9 targets involved in carcinogenesis.
- Examination of aberrant miR-9 expression patterns across different cancer types.
Main Results:
- Numerous miR-9 targets are integral to cancer development and are dysregulated in cancer cells.
- Aberrant miR-9 expression is a common finding in a majority of investigated cancers.
- miR-9 significantly influences cancer cell progression, with both down-regulation and up-regulation having distinct effects.
Conclusions:
- miR-9 is a critical regulator in the progression of various cancers.
- Understanding miR-9's regulatory functions is vital for its clinical application in cancer diagnosis, prognosis, and targeted therapy.
- Further research into miR-9's role can pave the way for novel miRNA-based cancer treatments.
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