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Related Experiment Videos

Cardiac output-changes during hemodialysis with ultrafiltration.

J F Vandenbogaerde1, R C Vanholder, J A Everaert

  • 1Department of Intensive Care, University Hospital, Ghent, Belgium.

Clinical Nephrology
|February 1, 1988
PubMed
Summary

Hemodialysis with ultrafiltration did not significantly alter overall cardiac output (CO). However, CO increased in patients with heart conditions but decreased in those without.

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Area of Science:

  • Cardiology
  • Nephrology
  • Physiology

Background:

  • Cardiovascular hemodynamics are crucial in patients undergoing chronic hemodialysis.
  • Ultrafiltration during hemodialysis can impact fluid balance and cardiac function.

Purpose of the Study:

  • To investigate the noninvasive cardiovascular hemodynamic response to hemodialysis with ultrafiltration.
  • To assess changes in cardiac output (CO) and mean blood pressure in patients on chronic hemodialysis.

Main Methods:

  • Noninvasive assessment of cardiovascular hemodynamics in 18 chronic hemodialysis patients.
  • Cardiac output (CO) measured using continuous wave Doppler before, during, and after hemodialysis.
  • Comparison of hemodynamic responses between patients with and without manifest myocardial disease.

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Main Results:

  • Overall cardiac output showed no significant change post-hemodialysis (7.8 +/- 0.6 l/min vs. 7.4 +/- 0.5 l/min pre-dialysis).
  • Mean blood pressure increased significantly from 103 +/- 4 mmHg to 113 +/- 3 mmHg post-hemodialysis.
  • In patients with myocardial infarction or dilated cardiomyopathy (n=12), CO significantly increased (7.3 +/- 0.7 to 8.4 +/- 0.6 l/min).
  • In patients without manifest myocardial disease (n=6), CO decreased (7.5 +/- 0.7 to 6.6 +/- 0.9 l/min), a significant intergroup difference (p<0.01).

Conclusions:

  • Hemodialysis with ultrafiltration may increase cardiac output in patients with pre-existing heart conditions like myocardial infarction or congestive cardiomyopathy.
  • Conversely, cardiac output may decrease in hemodialysis patients without manifest myocardial disease.
  • Individualized hemodynamic monitoring is important during hemodialysis, especially in patients with cardiovascular comorbidities.