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Extracellular Vesicles and Exosomes: Insights From Exercise Science.
Joshua P Nederveen1, Geoffrey Warnier2, Alessia Di Carlo1
1Department of Pediatrics, McMaster University Medical Centre (MUMC), Hamilton, ON, Canada.
Frontiers in Physiology
|February 18, 2021
Summary
Exercise releases bioactive molecules called exerkines, including extracellular vesicles (EVs), which mediate communication and adaptations. This review explores exercise
Area of Science:
- Exercise physiology
- Cellular biology
- Biochemistry
Background:
- Exercise benefits health and longevity through bioactive molecules (exerkines).
- Extracellular vesicles (EVs), including microvesicles (MVs) and exosomes (ELVs), are released during exercise.
- EVs are proposed mediators of intercellular communication and exercise adaptations.
Purpose of the Study:
- To review the effects of exercise on MVs and ELVs.
- To examine the role of EVs in exercise response and long-term adaptations.
- To highlight methodological challenges in EV research.
Main Methods:
- Literature review of studies on exercise and extracellular vesicles.
- Analysis of current understanding of EV function in exercise.
- Identification of challenges in blood collection, purification, and characterization of EVs.
Main Results:
- Exercise influences the release and content of MVs and ELVs.
- EVs play a role in mediating exercise-induced systemic adaptations.
- Significant methodological hurdles exist in studying exercise-related EVs.
Conclusions:
- EVs are key mediators in the adaptive response to exercise.
- Further research is needed to standardize EV isolation and characterization methods.
- Understanding exercise-EVs can inform strategies for health and longevity.
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