Related Experiment Video
Updated: Nov 17, 2025
04:59
Cheek Injection Model for Simultaneous Measurement of Pain and Itch-related Behaviors
Published on: September 27, 2019
12.7K
The neuropathic itch: Don't scratch your head too hard!
Soumya Patnaik1, John Brady Imms1, Gabor Varadi2
1Department of Medicine Einstein Medical Center Philadelphia PA USA.
Clinical Case Reports
|February 18, 2021
Summary
Postherpetic complications can cause significant debility. A multidisciplinary approach is vital for effective treatment strategies in affected patients.
Area of Science:
- Neurology
- Dermatology
- Pain Management
Background:
- Postherpetic neuralgia (PHN) is a common complication of herpes zoster (shingles).
- PHN can lead to chronic pain and significant patient debility.
- Optimal management requires a comprehensive understanding of its pathophysiology.
Observation:
- Patients experiencing postherpetic complications often present with debilitating symptoms.
- The severity of debility can impact quality of life.
- Individualized patient assessment is key.
Findings:
- A multidisciplinary approach is essential for managing postherpetic complications.
- This approach allows for tailored treatment strategies.
- Integrating various specialties improves patient outcomes.
Implications:
- Effective management of postherpetic complications can reduce patient debility.
- Multidisciplinary care enhances treatment efficacy.
- Further research into novel therapeutic strategies is warranted.
Related Concept Videos
01:16Sensory Functions of the Skin
7.1K
The skin is the largest organ of the human body and plays a crucial role in our sensory perception. It contains a vast network of sensory receptors that contribute to the skin's protective function by perceiving physical, biological, and environmental cues and generating relevant responses.
There are two main categories of receptors on the skin: capsulated and non-capsulated. The non-capsulated ones are mainly the pain receptors. The capsulated ones can be further categorized based on the...
There are two main categories of receptors on the skin: capsulated and non-capsulated. The non-capsulated ones are mainly the pain receptors. The capsulated ones can be further categorized based on the...
7.1K
01:44Nociception
32.2K
Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain.
32.2K
01:24Local Anesthetics: Differential Sensitivity of Nerve Fibers
1.2K
Local anesthetics (LAs) block the sodium channels of nerve trunks, sensory nerve endings, and neuromuscular junctions. Although LAs can block all kinds of nerves, the sensitivity of nerve fibers differs according to nerve types and structures. LAs are known to block myelinated fibers faster than unmyelinated ones. Also, they block pain or sensory neurons at low concentrations without affecting the motor neurons involved in muscle contractions. This helps relieve labor pain without affecting the...
1.2K
01:27Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
1.4K
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
1.4K
01:28Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists
373
Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy. SP binds and activates...
373