Related Experiment Video

Updated: Nov 17, 2025

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
06:46

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery

Published on: September 27, 2024

501

Improving Outcomes for Patients With Metastatic Colorectal Cancer: Challenges and Strategies

Leslie A Swanson1, Kathleen Boyle2

  • 1University of Washington/Seattle Cancer Care Alliance.

Journal of the Advanced Practitioner in Oncology
|February 18, 2021
PubMed

Insights

This review covers molecular testing and therapies for metastatic colorectal cancer (mCRC). It discusses emerging data on treatments and managing side effects for better patient outcomes.

Area of Science:

  • Oncology
  • Medical Practice

Background:

  • Metastatic colorectal cancer (mCRC) presents complex treatment challenges.
  • Guideline-concordant care is essential for optimizing patient outcomes.

Purpose of the Study:

  • To review current strategies for molecular testing in mCRC.
  • To discuss the clinical significance of emerging data for mCRC therapies.
  • To outline the management of adverse events in mCRC treatment.

Main Methods:

  • Review of guideline-concordant molecular testing protocols.
  • Analysis of clinical data for existing and novel therapeutic agents.
  • Discussion of adverse event management strategies.

Main Results:

  • Molecular testing is crucial for guiding therapy selection in mCRC.
  • Emerging data supports the efficacy of novel agents and refines the use of existing ones.
  • Effective management of adverse events improves treatment adherence and patient quality of life.

Conclusions:

  • Personalized therapy based on molecular profiling improves mCRC outcomes.
  • Continuous evaluation of emerging data is necessary for updating treatment guidelines.
  • Proactive management of side effects is integral to comprehensive mCRC care.

More Related Videos

Development and Maintenance of a Preclinical Patient Derived Tumor Xenograft Model for the Investigation of Novel Anti-Cancer Therapies09:29

Development and Maintenance of a Preclinical Patient Derived Tumor Xenograft Model for the Investigation of Novel Anti-Cancer Therapies

Published on: September 30, 2016

14.1K
Practical Considerations in Studying Metastatic Lung Colonization in Osteosarcoma Using the Pulmonary Metastasis Assay07:44

Practical Considerations in Studying Metastatic Lung Colonization in Osteosarcoma Using the Pulmonary Metastasis Assay

Published on: March 12, 2018

10.4K

Related Concept Videos

Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
6.0K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
8.1K
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.5K
Cancer Survival Analysis01:21

Cancer Survival Analysis

Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
523
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
9.1K