Integrating Best Practices to Improve Outcomes in Relapsed/Refractory Multiple Myeloma
Amy E Pierre1, Joshua Richter2
1Memorial Sloan Kettering Cancer Center, New York, New York.
Journal of the Advanced Practitioner in Oncology
|February 18, 2021
Summary
This review details current and novel treatments for relapsed/refractory multiple myeloma. It covers treatment mechanisms, clinical evidence, adverse events, and optimal therapy selection and sequencing strategies.
Area of Science:
- Hematology
- Oncology
- Clinical Pharmacy
Background:
- Multiple myeloma is a hematologic malignancy characterized by uncontrolled plasma cell growth.
- Relapsed/refractory multiple myeloma presents significant therapeutic challenges due to disease progression after initial treatments.
Purpose of the Study:
- To provide a comprehensive overview of approved and emerging therapies for relapsed/refractory multiple myeloma.
- To discuss the clinical data, mechanisms of action, and safety profiles of these treatments.
- To offer guidance on selecting and sequencing treatment strategies for optimal patient outcomes.
Main Methods:
- Review of recent clinical trials and published literature on multiple myeloma treatments.
- Analysis of mechanisms of action for various therapeutic agents.
- Synthesis of data on efficacy, safety, and patient-reported outcomes.
Main Results:
- Several novel therapeutic agents and combinations have demonstrated efficacy in relapsed/refractory multiple myeloma.
- Understanding the specific mechanisms of action is crucial for effective treatment selection.
- Adverse event profiles vary among treatments, requiring careful management.
Conclusions:
- Optimizing treatment for relapsed/refractory multiple myeloma requires a personalized approach based on disease characteristics and patient factors.
- Emerging therapies offer new hope and improved outcomes for patients with relapsed/refractory disease.
- Best practices in sequencing therapies can maximize treatment effectiveness and minimize toxicity.
More Related Videos
09:41An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells
Published on: July 15, 2015
8.9K
10:04Establishment of a Human Multiple Myeloma Xenograft Model in the Chicken to Study Tumor Growth, Invasion and Angiogenesis
Published on: May 1, 2015
13.3K
Related Concept Videos
02:56Treatment Resistant Cancers
3.5K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.5K
02:50Combination Therapies and Personalized Medicine
5.6K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.6K
02:57Targeted Cancer Therapies
8.1K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
8.1K
01:28Drug Therapy
153
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
Antianxiety Medications
153
01:22Bone Marrow Sampling and Transplants
636
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
636