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Preparation of Thermoresponsive Nanostructured Surfaces for Tissue Engineering
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Multifunctional Surfaces for Improving Soft Tissue Integration.

Adriana Vilaça1,2, Rui M A Domingues1,2, Hanna Tiainen3

  • 13B's Research Group, I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Avepark - Parque de Ciência e Tecnologia, Zona Industrial da Gandra, Barco, Guimarães, 4805-017, Portugal.

Advanced Healthcare Materials
|February 18, 2021
PubMed
Summary
This summary is machine-generated.

This study developed a novel metallic implant surface using cellulose nanocrystals (CNC) and platelet lysate (PL) biomolecules. The new surface promotes tissue integration and prevents implant-associated infections.

Keywords:
bacteriacellulose nanocrystalsfibroblastsmacrophagesplatelet lysatesoft tissue attachmenttitanium implants

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Tissue Engineering

Background:

  • Metallic implants are prone to infections and poor soft tissue integration.
  • Biomaterial-associated infections lead to inflammation and implant failure.

Purpose of the Study:

  • To develop a multifunctional implant surface promoting soft tissue integration and preventing infection.
  • To create nanoscale anisotropic surfaces using cellulose nanocrystals (CNC) and platelet lysate (PL) biomolecules.

Main Methods:

  • Fabrication of anisotropic radial nanopatterns on titanium using spin-coated CNC.
  • Coating CNC surfaces with bioactive molecules from PL.
  • Culturing fibroblasts and macrophages on the developed surfaces.

Main Results:

  • CNC nanopatterns guided fibroblast growth and alignment for 14 days.
  • PL biomolecules polarized macrophages towards an anti-inflammatory M2-like phenotype.
  • The multifunctional surface showed potential for promoting integration and preventing infection.

Conclusions:

  • The developed multifunctional surfaces enhance soft tissue integration with metallic implants.
  • These surfaces can prevent bacterial invasion and reduce inflammation, improving implant longevity.