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Related Experiment Video

Updated: Nov 17, 2025

Murine Model of Allergen Induced Asthma

Murine Model of Allergen Induced Asthma

Published on: May 14, 2012

Serum sphingolipid profile in asthma.

Chenglin Guo¹, Lina Sun¹, Linlin Zhang¹

¹Department of Pulmonary and Critical Care Medicine, Peking University Third Hospital, Beijing, China.

Journal of Leukocyte Biology

|February 18, 2021

Summary

Sphingomyelin (SM) levels are decreased in asthma patients, particularly in non-eosinophilic asthma. Lower SM may indicate a protective role and potential therapeutic target for asthma management.

Keywords:

ceramide eosinophilic asthma noneosinophilic asthma sphingomyelin

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Published on: December 17, 2017

Area of Science:

Biochemistry
Immunology
Metabolomics

Background:

Sphingolipid metabolism is crucial for cellular processes and implicated in asthma.
The specific role of sphingolipids in asthma pathogenesis and subtypes remains unclear.

Purpose of the Study:

To investigate the involvement of sphingolipids in asthma and its distinct subtypes.
To identify potential biomarkers and therapeutic targets within sphingolipid pathways.

Main Methods:

Serum samples from 51 asthma patients and 9 healthy controls were analyzed.
Liquid chromatography-mass spectrometry-based targeted metabolomics was employed to quantify serum sphingolipids.
Clinical data and sputum inflammatory markers were correlated with sphingolipid levels.

Main Results:

Significantly decreased levels of sphingomyelin (SM) (SM34:2, SM38:1, SM40:1) were observed in asthma patients compared to healthy individuals.
Serum SM levels were notably lower in the blood noneosinophilic asthma (bNEA) group versus the blood eosinophilic asthma group.
SM levels showed similar decreasing trends in early-onset asthma compared to late-onset asthma.
SM 40:1 demonstrated a negative correlation with sputum IL-17A levels.

Conclusions:

Sphingomyelin (SM) may act as a protective factor in asthma, particularly in the bNEA subtype.
Reduced SM levels are associated with asthma pathogenesis and specific inflammatory markers.
SM presents potential as a biomarker and therapeutic target for asthma treatment.