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Identifying PD-1/PD-L1 Inhibitors with Surface Plasmon Resonance Technology
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Immune checkpoint inhibitors

Guido Kroemer1,2,3,4,5, Laurence Zitvogel4,6,7,8,9

  • 1Equipe labellisée par la Ligue contre le cancer, Université de Paris, Sorbonne Université, Institut National de la Santé et de la Recherche Médicale U1138, Centre de Recherche des Cordeliers, Paris, France.

The Journal of Experimental Medicine
|February 18, 2021
PubMed

Three papers by James Allison and Tasuku Honjo published in JEM between 1995 and 2000 crystallized seminal insights into the role of CTLA-4 and PD-1 in immunosuppression (Krummel and Allison. 1995. J. Exp. Med.https://doi.org/10.1084/jem.182.2.459; van Elsas et al. 1999. J. Exp. Med.https://doi.org/10.1084/jem.190.3.355; Freeman et al. 2000. J. Exp. Med.https://doi.org/10.1084/jem.192.7.1027). These papers laid the basis for modern cancer immunotherapy and led to a shared 2018 Nobel Prize.

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