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Prognostic value of miR-142 in solid tumors: a meta-analysis
Rongqiang Liu1,2, Shiyang Zheng3, Kang Yu1
1Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi, China.
Bioscience Reports
|February 18, 2021
Summary
High microRNA 142 (miR-142) expression predicts better survival in solid tumors. This meta-analysis confirms miR-142 as a valuable prognostic marker for patients, improving overall and disease-free survival predictions.
Area of Science:
- Oncology
- Molecular Biology
- Biomarkers
Background:
- Conflicting results exist regarding the prognostic value of microRNA 142 (miR-142) in solid tumors.
- MicroRNAs play crucial roles in cancer development and progression.
- Identifying reliable prognostic markers is essential for personalized cancer treatment.
Purpose of the Study:
- To conduct a meta-analysis evaluating the prognostic significance of miR-142 in solid tumors.
- To consolidate existing evidence on the association between miR-142 expression levels and patient outcomes.
- To determine if miR-142 can serve as a predictive biomarker for solid tumor prognosis.
Main Methods:
- A comprehensive literature search was performed up to November 10, 2020, to identify relevant studies.
- Included studies investigated the prognostic role of miR-142 in solid tumors.
- Hazard ratios (HR) and 95% confidence intervals (CI) were calculated using a random-effects model; data analyzed with STATA 12.0.
Main Results:
- The meta-analysis included 20 articles with 2451 participants.
- High miR-142 expression was significantly associated with improved overall survival (OS) (HR = 0.66, 95% CI: 0.47-0.93).
- Elevated miR-142 levels also correlated with better disease-free/progression-free/recurrence-free survival (DFS/PFS/RFS) (HR = 0.71, 95% CI: 0.55-0.91).
Conclusions:
- MicroRNA 142 (miR-142) demonstrates significant potential as an effective prognostic marker in solid tumors.
- High miR-142 expression is linked to favorable patient survival outcomes.
- Further large-scale prospective studies are recommended to validate these findings and solidify miR-142's role in clinical practice.
