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CAM-Delam Assay to Score Metastatic Properties by Quantifying Delamination and Invasion Capacity of Cancer Cells

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Reprogramming the tumor metastasis cascade by targeting galectin-driven networks.

Ramiro M Perrotta¹, Camila A Bach¹, Mariana Salatino¹

¹Laboratorio de Inmunopatología, Instituto de Biología y Medicina Experimental (IBYME), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), C1428ADN Buenos Aires, Argentina.

The Biochemical Journal

|February 18, 2021

Summary

Galectins are key regulators of the metastatic cascade, influencing critical hallmarks of cancer metastasis like cell motility and colonization. Understanding galectin roles offers new therapeutic strategies against metastatic disease.

Keywords:

cancer galectins lectins metastasis tumor immunity

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Area of Science:

Oncology
Molecular Biology
Cell Biology

Background:

The metastatic cascade drives tumor progression through complex cellular and molecular interactions.
Metastasis is characterized by four key attributes: motility/invasion, microenvironment modulation, cell plasticity, and colonization.

Purpose of the Study:

To review the role of galectins in modulating each hallmark of metastasis.
To highlight galectin-targeted therapeutic opportunities for metastatic cancer.

Main Methods:

This review synthesizes current research on galectins and metastasis.
Focuses on the molecular mechanisms linking galectins to metastatic hallmarks.

Main Results:

Galectins are highly conserved proteins crucial in tumor microenvironments and metastasis sites.
Galectins modulate all four hallmarks of metastasis, influencing cancer cell behavior and spread.

Conclusions:

Galectins play a significant role in facilitating cancer metastasis.
Targeting galectins presents a promising therapeutic avenue for combating metastatic disease.