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Menstrual migraine: a distinct disorder needing greater recognition
Kjersti Grøtta Vetvik1, E Anne MacGregor2
1Department of Neurology, Akershus University Hospital, Lørenskog, Norway.
The Lancet. Neurology
|February 18, 2021
Summary
Menstrual migraine, affecting up to 25% of women, causes greater disability than other migraines. Current treatments lack robust evidence, necessitating further research into its distinct pathophysiology and effective therapies.
Area of Science:
- Neurology
- Gynecology
Background:
- Menstrual migraine is a distinct condition affecting 20-25% of female migraineurs.
- Perimenstrual migraine attacks cause significantly greater disability compared to non-menstrual attacks.
Purpose of the Study:
- To review the pathophysiology and treatment of menstrual migraine.
- To highlight the need for improved diagnostic criteria and research.
Main Methods:
- Literature review of existing studies on menstrual migraine.
- Analysis of diagnostic criteria and pathophysiological mechanisms.
Main Results:
- Prevalence varies due to loose diagnostic criteria.
- Oestrogen withdrawal and prostaglandin release are identified mechanisms.
- Evidence for current management strategies is not robust.
Conclusions:
- Menstrual migraine is common and debilitating, requiring more research.
- Improved understanding of pathophysiology is crucial for developing effective treatments.
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