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Hyperphosphatemia rather than hypophosphatemia indicates a poor prognosis in patients with sepsis

Huabin Wang1, Lidan Zhang1, Wenhua Liao2

  • 1Division of Hematology/Oncology, Department of Pediatrics, the Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen 518107, China; Department of Pediatric Intensive Care Unit, the Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen 518107, China.

Clinical Biochemistry
|February 18, 2021
PubMed

Insights

High serum phosphorus (hyperphosphatemia) indicates a poor prognosis in sepsis patients, while low levels do not significantly impact survival. Early identification of high-risk sepsis patients is crucial.

Area of Science:

  • Critical Care Medicine
  • Clinical Chemistry
  • Prognostic Biomarkers

Background:

  • Sepsis is a primary cause of intensive care unit mortality.
  • Identifying high-risk sepsis patients early is essential for improved outcomes.
  • Serum phosphorus levels are investigated as potential prognostic indicators in sepsis.

Purpose of the Study:

  • To evaluate the prognostic significance of serum phosphorus levels in sepsis patients.
  • To determine if hyperphosphatemia or hypophosphatemia predicts mortality in sepsis.

Main Methods:

  • Analysis of 4767 sepsis patients from the MIMIC-III database.
  • Utilized Locally Weighted Scatterplot Smoothing and Kaplan-Meier analysis for initial assessment.
  • Multivariable logistic regression and subgroup analyses were performed to assess in-hospital mortality.

Main Results:

  • Hyperphosphatemia showed a significant correlation with in-hospital mortality (OR 1.48, 95% CI 1.19-1.85).
  • Hypophosphatemia did not demonstrate a significant association with in-hospital mortality (OR 0.91, 95% CI 0.70-1.19).
  • No significant interactions were found between serum phosphorus levels and renal failure, vasopressin use, or SOFA score.

Conclusions:

  • Elevated serum phosphorus (hyperphosphatemia) is a significant indicator of poor prognosis in sepsis.
  • Low serum phosphorus (hypophosphatemia) is not associated with increased mortality in sepsis patients.
Abstract

Keywords:
Prognostic valuesSepsisSerum phosphorus

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