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Commentary: Dandrolene for Ischemia-Reperfusion: Ready for Clinical Translation?

Edward Buratto1, Igor E Konstantinov2

  • 1Department of Cardiac Surgery, Royal Children's Hospital, Melbourne, VIC, Australia; Department of Paediatrics, University of Melbourne, Melbourne, VIC, Australia; Heart Research Group, Murdoch Children's Research Institute, Murdoch Children's Research Institute, Melbourne, VIC, Australia.

Seminars in Thoracic and Cardiovascular Surgery
|February 18, 2021
PubMed
Abstract

No abstract available in PubMed .

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Directly acting muscle relaxants like dantrolene and botulinum toxin (BoNT) have distinct mechanisms and applications. Dantrolene, a hydantoin derivative, acts on the ryanodine receptor (RYR1) in skeletal muscle cells. RYR1 are calcium channels present at the sarcoplasmic reticulum membrane. In response to excitation, they release calcium ions from the sarcoplasmic reticulum to the cytosol. Calcium promotes actin-myosin-mediated contraction of muscles.
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