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A review on the role of oncogenic lncRNA OIP5-AS1 in human malignancies

Soudeh Ghafouri-Fard1, Sepideh Dashti1, Molood Farsi2

  • 1Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|February 18, 2021
PubMed

Insights

OIP5-AS1, a long non-coding RNA, plays a critical role in cancer development by regulating cell cycles and acting as a competing endogenous RNA. Its elevated expression in most cancers highlights its potential as a cancer biomarker.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • OIP5-AS1 is a long non-coding RNA (lncRNA) highly expressed in the nervous system.
  • This lncRNA is implicated in neoplastic transformation and regulates cell cycle progression.
  • OIP5-AS1 functions as a competing endogenous RNA (ceRNA) for numerous microRNAs (miRNAs).

Purpose of the Study:

  • To comprehensively review and synthesize existing research on the function of OIP5-AS1 in various cancer types.
  • To consolidate findings on OIP5-AS1's role in carcinogenesis, including its interaction with miRNAs and modulation of epithelial-mesenchymal transition (EMT).

Main Methods:

  • Literature review and compilation of research papers evaluating OIP5-AS1 function in cancer.
  • Analysis of OIP5-AS1's molecular mechanisms, including its role as a ceRNA and its impact on cellular processes.

Main Results:

  • OIP5-AS1 expression is elevated in most neoplastic tissues, with exceptions like multiple myeloma.
  • Conflicting expression data exists for OIP5-AS1 in bladder, gastric, and lung cancers.
  • OIP5-AS1 influences carcinogenesis through pathways including EMT and miRNA sponging.

Conclusions:

  • OIP5-AS1 is a significant lncRNA involved in multiple cancer types.
  • Further research is needed to clarify its role in specific cancers with conflicting expression data.
  • OIP5-AS1's functions as a ceRNA and regulator of EMT present therapeutic and diagnostic opportunities.
Keywords:
CancerLncRNAOIP5OIP5-AS1

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