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Related Experiment Video

Updated: Nov 17, 2025

Developing a Rat Model for Bipolar Disorder

Developing a Rat Model for Bipolar Disorder

Published on: May 2, 2025

Interpretation bias training for bipolar disorder: A randomized controlled trial.

Anna Van Meter¹, Joel Stoddard², Ian Penton-Voak³

¹Feinstein Institutes for Medical Research, Institute of Behavioral Science; The Zucker Hillside Hospital, Department of Psychiatry Research; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Glen Oaks, New York.

Journal of Affective Disorders

|February 19, 2021

Summary

Interpretation bias training (IBT) reduced depressed mood and improved social function in young adults with bipolar disorder (BD). This accessible intervention may complement existing treatments for BD by shifting negative emotion interpretation biases.

Keywords:

Bipolar disorder Depression Operant learning Social cognition Social support

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Design and Implementation of an fMRI Study Examining Thought Suppression in Young Women with, and At-risk, for Depression

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Published on: May 19, 2015

Area of Science:

Psychiatry
Clinical Psychology
Cognitive Behavioral Therapy

Background:

Bipolar disorder (BD) is characterized by emotion interpretation biases that can worsen depressive symptoms.
The

Purpose of the Study:

To investigate if interpretation bias training (IBT) can alter emotion interpretation biases in individuals with BD.
To assess the clinical effectiveness of IBT in reducing depressed mood and enhancing social functioning in people with BD.

Main Methods:

A randomized controlled trial involving young adults with BD undergoing computer-based IBT.
Participants were assigned to either active IBT, targeting negative bias towards positive interpretations, or a sham IBT condition.
Mood and social functioning were assessed at baseline, 2 weeks, and 10 weeks post-intervention.

Main Results:

IBT significantly shifted emotion interpretations, with a large effect size (Hedges g = 1.63).
The active IBT group showed a significantly greater reduction in self-reported depression compared to the sham group (B = -13.88, p < .0001).
Improvements were also observed in perceived familial support, and faster learning rates during IBT predicted greater reductions in depression.

Conclusions:

Interpretation bias training (IBT) is effective in reducing depressed mood in individuals with bipolar disorder (BD).
The findings support the role of operant conditioning principles in depression treatment and suggest IBT as a potentially valuable, low-cost adjunct therapy for BD.