Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Development of Antibiotic Resistance01:30

Development of Antibiotic Resistance

789
Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
789
Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic01:26

Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic

5.1K
Healthcare-associated infections (HAIs) occur in a healthcare facility while a person receives care for another ailment. This category also includes work-related infections among healthcare staff.
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies.
5.1K
Healthcare Associated Infections II: Preventive Measures01:22

Healthcare Associated Infections II: Preventive Measures

3.4K
Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
3.4K
Introduction to Epidemiology01:26

Introduction to Epidemiology

1.3K
Epidemiology, known as the cornerstone of public health, involves studying the distribution and determinants of health-related events in defined populations and applying these insights to control health issues. This is essential for understanding how diseases spread, identifying populations at greater risk, and implementing measures to control or prevent outbreaks. Epidemiology addresses not only infectious diseases but also non-communicable conditions like cancer and cardiovascular disease,...
1.3K
Antimicrobial Effectiveness01:28

Antimicrobial Effectiveness

750
The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
750
Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

13.0K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
13.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cytopeutics umbilical cord-derived mesenchymal stem cells are associated with earlier clinical improvement compared to bone marrow aspirate concentrate with scaffold in knee cartilage injury: A Phase 1 feasibility and Phase 2 randomized controlled trial.

The Medical journal of Malaysia·2026
Same author

Prevalence and factors associated with seizures among patients with infective encephalitis.

The Medical journal of Malaysia·2026
Same author

Dental caries among 6-year-olds in Ajman, UAE: a cross-sectional study.

European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry·2025
Same author

Utilisation of the Malaysian BRCA variants database to construct a target panel for biosensor-based genetic breast cancer screening.

The Malaysian journal of pathology·2025
Same author

Influence of molar incisor hypomineralization on oral health-related quality of life in 8-10-year-old children: a cross-sectional study.

European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry·2025
Same author

Dental caries and PROP genetic taste predisposition in UAE 7-10 years old.

European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry·2025

Related Experiment Video

Updated: Nov 17, 2025

Characterization of a Pathogenic Escherichia coli Strain Derived from Oreochromis spp. Farms Using Whole-Genome Sequencing
09:44

Characterization of a Pathogenic Escherichia coli Strain Derived from Oreochromis spp. Farms Using Whole-Genome Sequencing

Published on: December 23, 2022

2.6K

Carbapenem-Resistant Enterobactericeae: ClinicoEpidemiological Perspective.

N A Mohamed1, H M Said1, H Hussin

  • 1Faculty of Medicine and Health Sciences, Universiti Sains Islam Malaysia, Kuala Lumpur, Malaysia.

Tropical Biomedicine
|February 19, 2021
PubMed
Summary
This summary is machine-generated.

Carbapenem-resistant Enterobacteriaceae (CRE) infections are a growing concern, especially in immunocompromised patients. This study found a low prevalence of CRE in a Malaysian hospital, but a high rate of co-occurring resistance genes like NDM-1 and OXA-48.

More Related Videos

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes
08:58

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes

Published on: March 3, 2023

7.2K
Antimicrobial Synergy Testing by the Inkjet Printer-assisted Automated Checkerboard Array and the Manual Time-kill Method
12:03

Antimicrobial Synergy Testing by the Inkjet Printer-assisted Automated Checkerboard Array and the Manual Time-kill Method

Published on: April 18, 2019

26.9K

Related Experiment Videos

Last Updated: Nov 17, 2025

Characterization of a Pathogenic Escherichia coli Strain Derived from Oreochromis spp. Farms Using Whole-Genome Sequencing
09:44

Characterization of a Pathogenic Escherichia coli Strain Derived from Oreochromis spp. Farms Using Whole-Genome Sequencing

Published on: December 23, 2022

2.6K
Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes
08:58

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes

Published on: March 3, 2023

7.2K
Antimicrobial Synergy Testing by the Inkjet Printer-assisted Automated Checkerboard Array and the Manual Time-kill Method
12:03

Antimicrobial Synergy Testing by the Inkjet Printer-assisted Automated Checkerboard Array and the Manual Time-kill Method

Published on: April 18, 2019

26.9K

Area of Science:

  • Clinical Microbiology
  • Infectious Diseases
  • Antimicrobial Resistance

Background:

  • Carbapenem-resistant Enterobacteriaceae (CRE) are multidrug-resistant organisms causing severe healthcare-associated infections.
  • Limited treatment options and high mortality rates make CRE a significant public health threat.
  • Understanding CRE prevalence and resistance patterns is crucial for effective infection control.

Purpose of the Study:

  • To determine the prevalence of CRE at a tertiary hospital in Selangor, Malaysia.
  • To identify the common species and resistance genes associated with CRE isolates.
  • To analyze the antimicrobial susceptibility patterns of CRE.

Main Methods:

  • Retrospective analysis of CRE culture results from January 2015 to December 2016.
  • Isolate identification using conventional and Vitek 2® methods.
  • Antimicrobial susceptibility testing via disk diffusion and E-test, with PCR for specific resistance genes (NDM-1, KPC, OXA-48, VIM, IMP).

Main Results:

  • CRE prevalence was 0.3% in 2015 and 1.2% in 2016.
  • Klebsiella pneumoniae was the predominant species (81.8%).
  • High prevalence of NDM-1 and OXA-48 co-producing Klebsiella pneumoniae (41%) was observed, alongside resistance to cephalosporins, carbapenems, tigecycline, polymyxin B, and colistin.

Conclusions:

  • The overall prevalence of CRE in this Malaysian hospital was low, but concerning trends were noted.
  • Co-production of NDM-1 and OXA-48 genes is a significant finding in CRE isolates.
  • Increased clinical suspicion for CRE in hematological patients is recommended due to high resistance rates.