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Bruch's membrane opening-minimum rim width: An alternative OCT biomarker study for multiple sclerosis.

Kemal Turgay Özbilen1, Tuncay Gündüz2, Selva Nur Çukurova Kartal1

  • 1Department of Ophthalmology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.

European Journal of Ophthalmology
|February 19, 2021
PubMed
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The anatomic positioning system-retinal nerve fiber layer (APS-RNFL) OCT technique shows promise as a reliable biomarker for multiple sclerosis (MS) patients, outperforming Bruch

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Bruch’s membrane opening-minimum rim widthMultiple sclerosisanatomic positioning systemretinal nerve fiber layerspectral-domain optical coherence tomography

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Area of Science:

  • Ophthalmology
  • Neuroscience
  • Medical Imaging

Background:

  • Multiple Sclerosis (MS) is a demyelinating disease affecting the central nervous system.
  • Optical Coherence Tomography (OCT) is a non-invasive imaging technique used to visualize retinal layers.
  • Novel OCT parameters, including Bruch's membrane opening-minimum rim width (BMO-MRW) and anatomic positioning system-retinal nerve fiber layer (APS-RNFL), require investigation in MS.

Purpose of the Study:

  • To evaluate novel spectral-domain OCT parameters as potential biomarkers in patients with multiple sclerosis (MS).
  • To compare the efficacy of APS-RNFL and BMO-MRW with standard RNFL (S-RNFL) measurements in MS patients.

Main Methods:

  • Retrospective cohort study including relapsing-remitting MS (RRMS) patients and healthy controls (HC).
  • Eyes were classified based on MS diagnosis and history of optic neuritis (ON).
  • Measurements included S-RNFL, BMO-MRW, and APS-RNFL.

Main Results:

  • Neuroretinal rim thicknesses were thinnest in eyes with a history of ON across measured parameters.
  • Both S-RNFL and APS-RNFL differentiated between ON+, ON-, and HC groups.
  • BMO-MRW failed to distinguish between ON(-) patients and HC, and was statistically weaker than RNFL techniques.

Conclusions:

  • The APS-RNFL technique is a more reliable alternative to S-RNFL for supporting therapeutic decisions in MS.
  • BMO-MRW is not a successful alternative to S-RNFL for MS assessment.
  • OCT parameters, particularly APS-RNFL, show potential for risk stratification in MS patients.