Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Nonlinear Pharmacokinetics: Dependence of Elimination Half-Life and Dose Clearance01:23

Nonlinear Pharmacokinetics: Dependence of Elimination Half-Life and Dose Clearance

420
The elimination half-life and drug clearance of drugs following nonlinear kinetics can vary with dosage. The Michaelis-Menten parameters and drug concentration influence these factors. As the dose increases, the elimination half-life tends to lengthen, resulting in a reduction in clearance and a disproportionately larger area under the curve. The total clearance can be derived from the Michaelis-Menten equation for drugs following a one-compartment model.
A study on guinea pigs examined the...
420
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

89
Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
89
Drug Concentration Versus Time Correlation01:15

Drug Concentration Versus Time Correlation

1.6K
The plasma drug concentration-time curve is a crucial tool in pharmacokinetics, representing the drug's concentration in plasma at different time intervals post-administration. This curve illustrates the drug's journey from absorption into the systemic circulation, distribution to body tissues, and eventual elimination through excretion or biotransformation.
Two pivotal parameters are the minimum effective concentration (MEC) and the minimum toxic concentration (MTC). The MEC is the...
1.6K
Antiarrhythmic Drugs: Class III Agents as Potassium Channel Blockers01:12

Antiarrhythmic Drugs: Class III Agents as Potassium Channel Blockers

1.5K
Class III antiarrhythmic drugs are a group of medications that can prolong action potentials in the heart. They achieve this by blocking potassium channels or enhancing inward currents from sodium channels. However, these drugs have a unique property of "reverse use-dependence," which is most pronounced at slower heart rates and can lead to torsades de pointes—a specific type of arrhythmia. However, it is essential to note that excessive QT interval prolongation—a measure of...
1.5K
Time Course of Drug Effect01:14

Time Course of Drug Effect

2.4K
The progression of a drug's impact can be analyzed by examining both the concentration-time course and the effect-time course. The concentration-time course is determined by the drug's half-life and is influenced by factors such as its pharmacokinetics, including absorption, distribution, metabolism, and elimination. The effect of the drug is often related to its concentration in the plasma and is calculated using the maximum drug effect and the plasma concentration that generates 50...
2.4K
Opioid Analgesics: Synthetic and Semisynthetic Opioids01:15

Opioid Analgesics: Synthetic and Semisynthetic Opioids

649
Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
649

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Association of Glucose-Lowering Therapy with Myocardial Work Recovery and Reverse Remodeling After STEMI.

Journal of clinical medicine·2026
Same author

Superstructural Assembly of Ag<sub>24</sub> Nanoclusters with Different Ligands Exhibiting Mechanoresponsive Luminescence.

Inorganic chemistry·2026
Same author

TYK2 signaling as a molecular bridge between cytokine storm and chronic inflammation: therapeutic implications of deucravacitinib.

Molecular biology reports·2026
Same author

Near-Infrared Theranostics: Cutting-Edge Innovations in Cancer Diagnosis and Therapy.

Anti-cancer agents in medicinal chemistry·2026
Same author

Comparative effectiveness of Mandibular advancement devices and Continuous positive airway pressure in adults with obstructive sleep Apnea: A systematic review and meta-analysis.

Sleep medicine·2026
Same author

ASO Visual Abstract: Watch and Wait Versus Surgery for Rectal Cancer-Markov Modelling-Derived Thresholds for Salvage, Regrowth, and Near-Complete Responders.

Annals of surgical oncology·2026

Related Experiment Video

Updated: Nov 17, 2025

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry
10:17

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry

Published on: April 23, 2019

10.0K

Opium-associated QT Interval Prolongation: A Cross-sectional Comparative Study.

Ankit Sharma1

  • 1Department of Anesthesia and Intensive Care, Govind Ballabh Pant Institute of Postgraduate Medical Education and Research, New Delhi, India.

Indian Journal of Critical Care Medicine : Peer-Reviewed, Official Publication of Indian Society of Critical Care Medicine
|February 19, 2021
PubMed
Summary

Opium use can prolong the QT interval, increasing the risk of dangerous heart rhythms. This study compared QT intervals in opium users versus non-users, highlighting a significant association.

Keywords:
DepolarizationOpium toxicityQT prolongation

More Related Videos

Methods for ECG Evaluation of Indicators of Cardiac Risk, and Susceptibility to Aconitine-induced Arrhythmias in Rats Following Status Epilepticus
08:28

Methods for ECG Evaluation of Indicators of Cardiac Risk, and Susceptibility to Aconitine-induced Arrhythmias in Rats Following Status Epilepticus

Published on: April 5, 2011

18.0K
Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery
09:38

Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery

Published on: April 14, 2016

12.9K

Related Experiment Videos

Last Updated: Nov 17, 2025

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry
10:17

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry

Published on: April 23, 2019

10.0K
Methods for ECG Evaluation of Indicators of Cardiac Risk, and Susceptibility to Aconitine-induced Arrhythmias in Rats Following Status Epilepticus
08:28

Methods for ECG Evaluation of Indicators of Cardiac Risk, and Susceptibility to Aconitine-induced Arrhythmias in Rats Following Status Epilepticus

Published on: April 5, 2011

18.0K
Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery
09:38

Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery

Published on: April 14, 2016

12.9K

Area of Science:

  • Cardiology
  • Clinical Pharmacology
  • Toxicology

Background:

  • Opium, a potent opioid derived from the opium poppy, contains numerous alkaloids with known cardiovascular effects.
  • QT interval prolongation is a critical indicator of potential cardiac arrhythmia, including Torsades de Pointes.
  • Understanding the specific cardiac risks associated with opium use is essential for clinical management and public health.

Discussion:

  • The study investigated the association between opium consumption and QT interval prolongation, a known risk factor for fatal arrhythmias.
  • Findings suggest a potential direct or indirect effect of opium alkaloids on cardiac ion channels, leading to delayed repolarization.
  • Clinical implications include the need for vigilant cardiac monitoring in patients with a history of opium use.

Key Insights:

  • Opium-associated cardiac dysfunction may manifest as significant QT interval prolongation.
  • A comparative analysis revealed a higher prevalence of prolonged QT intervals in opium users compared to controls.
  • This highlights a previously under-recognized cardiovascular risk of recreational and therapeutic opium use.

Outlook:

  • Further research is warranted to elucidate the precise electrophysiological mechanisms underlying opium-induced QT prolongation.
  • Prospective studies could evaluate the long-term cardiovascular outcomes and the efficacy of interventions in affected individuals.
  • This study underscores the importance of considering opium use in the differential diagnosis of unexplained QT prolongation.