The effect of denosumab administration on bone metabolism for treatment of spinal metastasis
Katsuhisa Kawanami1, Atsuhiko Hirasawa1, Masataka Deie1
1Department of Orthopedic Surgery, Aichi Medical University, Nagakute, Aichi, Japan.
Background:
We investigated changes in bone metabolism markers over time for evaluating the effect of denosumab following administration to patients with spinal metastasis.
Methods:
Subjects of this study were 28 patients treated at the Department of Orthopedic Surgery at Aichi Medical University.
Results:
At 6 months after denosumab intervention, measured TRAP-5b values were significantly lower compared to pre-intervention values in both the osteosclerotic lesion and osteolytic lesion groups.
Conclusions:
This change in bone metabolism marker values over time is one of the methods for evaluating the effect of treatment on bone tissue in cases of spinal metastasis.
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