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Lipid Index Determination by Liquid Fluorescence Recovery in the Fungal Pathogen Ustilago Maydis
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Hyperlipidemia Caused by Voriconazole: A Case Report.
Jiasheng Wu1,2, Na Chen3, Yake Yao1
1Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310003, People's Republic of China.
Infection and Drug Resistance
|February 19, 2021
Summary
Voriconazole, a common antifungal, may cause significant increases in triglycerides and cholesterol. This case study suggests a link between voriconazole levels and drug-induced dyslipidemia, highlighting the need for monitoring.
Area of Science:
- Pharmacology
- Clinical Medicine
Background:
- Voriconazole is a widely used triazole antifungal agent with established adverse effects.
- Adverse reactions like visual impairment, hepatotoxicity, and skin rash are documented.
- Few reports link triazole antifungals to increased triglyceride and total cholesterol levels.
Observation:
- A patient with chronic pulmonary aspergillosis presented with elevated baseline triglyceride levels.
- Treatment with voriconazole led to a significant increase in both triglyceride and total cholesterol.
- Lipid levels improved upon voriconazole withdrawal and re-elevated upon its reintroduction.
Findings:
- The patient experienced marked increases in triglyceride and total cholesterol during voriconazole therapy.
- Lipid levels normalized after discontinuing voriconazole and initiating itraconazole.
- Re-challenge with voriconazole resulted in recurrent hypertriglyceridemia, suggesting a causal relationship.
Implications:
- This case highlights a potential link between voriconazole and drug-induced dyslipidemia.
- The severity of dyslipidemia appears correlated with voriconazole trough concentrations.
- Monitoring lipid profiles in patients receiving voriconazole may be warranted.
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