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Updated: Nov 17, 2025

Deep Brain Stimulation with Simultaneous fMRI in Rodents
Published on: February 15, 2014
Numerical Study on Electrode Design for Rodent Deep Brain Stimulation With Implantations Cranial to Targeted Nuclei
Konstantin Butenko1, Rüdiger Köhling2,3, Ursula van Rienen1,4
1Institute of General Electrical Engineering, University of Rostock, Rostock, Germany.
Abstract:
The globus pallidus internus and the subthalamic nucleus are common targets for deep brain stimulation to alleviate symptoms of Parkinson's disease and dystonia. In the rodent models, however, their direct targeting is hindered by the relatively large dimensions of applied electrodes. To reduce the neurological damage, the electrodes are usually implanted cranial to the nuclei, thus exposing the non-targeted brain regions to large electric fields and, in turn, possible undesired stimulation effects. In this numerical study, we analyze the spread of the fields for the conventional electrodes and several modifications. As a result, we present a relatively simple electrode design that allows an efficient focalization of the stimulating field in the inferiorly located nuclei.
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