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Published on: November 7, 2017
Correlations of cardiac function with inflammation, oxidative stress and anemia in patients with uremia
Heping Zhang1, Lei Fan1, Huawei Liao1
1Department of Renal Medicine, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, P.R. China.
Insights
Inflammation, oxidative stress, and anemia are linked to heart problems in uremia patients. Higher levels of these markers correlate with reduced heart function, particularly lower left ventricular ejection fraction.
Area of Science:
- Nephrology
- Cardiology
- Biochemistry
Background:
- Uremia, a condition of kidney failure, is associated with cardiovascular complications.
- Cardiac dysfunction is a significant concern in patients with uremia.
Purpose of the Study:
- To investigate the relationship between cardiac function and markers of inflammation, oxidative stress, and anemia in uremic patients.
- To identify specific biomarkers associated with cardiac insufficiency in this population.
Main Methods:
- A cohort of 79 uremic patients was divided into two groups: those with cardiac dysfunction (n=43) and those without (n=36).
- Measurements included inflammatory cytokines (CRP, IL-6, IL-10), oxidative stress indicators (MDA, OX-LDL, AOPP), blood parameters (Hb, PLT, MCV), and cardiac function indices (CO, SV, LVEF, LVEDd, LVESd).
Main Results:
- Patients with cardiac dysfunction exhibited higher levels of triglycerides, blood pressure, and longer uremia duration.
- Elevated levels of inflammatory cytokines, oxidative stress markers, and anemia indicators were observed in the cardiac dysfunction group.
- Cardiac function was impaired in the observation group, with decreased cardiac output, stroke volume, and left ventricular ejection fraction, and increased left ventricular dimensions.
Conclusions:
- Serum inflammatory cytokines, oxidative stress markers, and the degree of anemia are significantly associated with cardiac insufficiency in patients with uremia.
- C-reactive protein and malondialdehyde levels showed a negative correlation with left ventricular ejection fraction, while hemoglobin levels demonstrated a positive correlation.
Abstract:
The present study aimed to analyze the associations of cardiac function with inflammatory cytokines, oxidative stress and anemia in patients with uremia. A total of 79 patients with uremia were selected, and among those, 43 cases were complicated with cardiac dysfunction (observation group) and 36 patients were not (control group). The levels of inflammatory cytokines [C-reactive protein (CRP), interleukin-6 (IL-6) and IL-10], oxidative stress indicators [malondialdehyde (MDA), oxidized low-density lipoprotein (OX-LDL) and advanced oxidation protein products (AOPP)], blood routine parameters [hemoglobin (Hb), platelets (PLT), mean corpuscular volume (MCV)], and cardiac function [including cardiac output (CO), cardiac stroke volume (SV), left ventricular ejection fraction (LVEF), left ventricular end-diastolic diameter (LVEDd) and left ventricular end-systolic diameter (LVESd)] were measured. There were no statistically significant differences in age, sex, body mass index, total cholesterol, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol between the observation and the control group (P>0.05), but the observation group had significantly higher triglyceride levels and blood pressure, as well as longer duration of uremia compared with those in the control group (P<0.05). Furthermore, the levels of CRP, IL-6, IL-10, MDA, OX-LDL, AOPP, Hb, PLT and MCV in the observation group were significantly higher than those in the control group. In addition, regarding cardiac function, the observation group had a decreased CO, SV and LVEF and an increased LVEDd and LVESd compared with those in the control group. Furthermore, CRP (r=-0.636, P<0.01) and MDA (r=-0.705, P<0.01) were negatively correlated with LVEF, while Hb levels were positively correlated with LVEF (r=0.732, P<0.001). In conclusion, serum inflammatory cytokines, oxidative stress and the degree of anemia are associated with cardiac insufficiency in patients with uremia.
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