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A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks
Published on: June 26, 2020
10.1K
Enterically transmitted hepatitis in the third millennium in northeastern Romania.
Ioana Florina Mihai1,2, Carmen Manciuc1,2, Ioana Maria Hunea1,2
1Department of Infectious Diseases, 'Sf. Parascheva' Clinical Hospital of Infectious Diseases, 700116 Iasi, Romania.
Experimental and Therapeutic Medicine
|February 19, 2021
Summary
Hepatitis E virus (HEV) is increasingly diagnosed in developed nations, unlike Hepatitis A virus (HAV). HEV infections may be underdiagnosed, often presenting asymptomatically, posing risks to vulnerable populations.
Area of Science:
- Hepatology
- Infectious Diseases
- Public Health
Background:
- Hepatitis A virus (HAV) incidence is declining, while Hepatitis E virus (HEV) is rising globally, particularly in developed countries.
- Both viral hepatitis infections are linked to socio-economic factors and remain significant public health concerns worldwide.
- Viral hepatitis diagnosis and management require ongoing surveillance and understanding of transmission dynamics.
Purpose of the Study:
- To analyze the epidemiological characteristics of hospitalized viral hepatitis cases in Romania.
- To compare the incidence and clinical presentation of Hepatitis A virus (HAV) and Hepatitis E virus (HEV) infections.
- To highlight the potential underdiagnosis and public health implications of HEV infection.
Main Methods:
- Retrospective analysis of medical records from patients hospitalized with viral hepatitis.
- Inclusion of serologically confirmed cases of HAV and HEV infections between 2018 and 2019.
- Data collection on patient demographics, clinical presentation, and outcomes.
Main Results:
- A total of 269 HAV-infected patients were analyzed, with males (53.9%) and adolescents aged 8-15 years (53.6%) being the most affected.
- Severe HAV infections occurred in 2.24% of cases, with favorable outcomes under supportive treatment.
- Only three adult males were confirmed with HEV infection, suggesting potential underreporting or asymptomatic cases, despite a regional seroprevalence of 32.5%.
Conclusions:
- Hepatitis A virus (HAV) outbreaks continue in the region, predominantly affecting young males.
- Hepatitis E virus (HEV) infection appears underdiagnosed and underreported, possibly due to asymptomatic or subclinical presentations.
- HEV poses significant risks to vulnerable groups, including pregnant women and immunocompromised individuals, necessitating further investigation and public health strategies.
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