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Utility of Dissociated Intrinsic Hand Muscle Atrophy in the Diagnosis of Amyotrophic Lateral Sclerosis
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Subacute Onset Sensorimotor Axonal Neuropathy with Sicca Syndrome
Ioan-Cristian Lupescu1, Mirela Ramona Draghici1, Oana Maria Obrisca1
1Neurology Department, Fundeni Clinical Institute, Bucharest, Romania.
Maedica
|February 19, 2021
Summary
This case study highlights Sjögren syndrome-associated peripheral neuropathy with cryoglobulinemia in a 65-year-old female. Early diagnosis and treatment, including plasma exchange, led to partial improvement in gait disturbance.
Area of Science:
- Neurology
- Rheumatology
- Immunology
Background:
- A 65-year-old female presented with painful peripheral neuropathy, gait disturbance, and sicca symptoms.
- Cervical MRI revealed an enlarged parotid gland, prompting further investigation.
Discussion:
- Electroneurography confirmed chronic sensorimotor axonal neuropathy with active denervation.
- Laboratory findings included anti-SS-A/SS-B antibodies, cryoglobulinemia, and monoclonal bands (IgM and kappa light chain).
Key Insights:
- The patient was diagnosed with Sjögren syndrome-associated peripheral neuropathy and cryoglobulinemia.
- Extensive workup, including bone marrow aspiration, ruled out malignancy.
Outlook:
- Plasma exchange treatment resulted in partial improvement of the patient's gait.
- This case underscores the importance of recognizing Sjögren syndrome as a cause of peripheral neuropathy.
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