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Updated: Nov 17, 2025

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
Investigation on the Anticancer Activity of Symmetric and Unsymmetric Cyclic Sulfamides
Jaden Jungho Jun1,2, Divya Duscharla3, Ramesh Ummanni3
1Department of Pharmaceutical Sciences and Computational Chemical Genomics Screening Center, National Institutes of Health (NIH) National Center of Excellence for Computational Drug Abuse Research, Drug Discovery Institute, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, United States.
Abstract:
The sulfamide functional group has been extensively employed in organic synthesis to discover probes and drugs in various applications such as cancer, human immunodeficiency virus (HIV), virus, and diabetes. Herein, we describe the synthesis of 7-membered symmetric and unsymmetric sulfamide compounds and their biological evaluation through the National Cancer Institute (NCI) panel of 60 human tumor cell lines (NCI-60) and the mechanism of action study. The results of a study from the NCI-60 cell line exhibited that many synthesized cyclic sulfamide compounds inhibited breast cancer (MDA-MB-468). The mechanism of action study of a representative compound 18 showed the inhibition of proliferation and apoptosis in A549 lung cancer cells.
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