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Durable response achieved using Pazopanib for germ tumor cells: A case report
Yuta Takezawa1,2, Hiroshi Yaegashi1, Masashi Iijima1
1Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa 920-8641, Japan.
Molecular and Clinical Oncology
|February 19, 2021
Summary
Germ cell tumors with somatic-type malignancy (GCTSTM) are rare and aggressive. Pazopanib demonstrated a rare, durable response in a patient with GCTSTM, offering a potential new treatment avenue.
Area of Science:
- Oncology
- Medical Case Reports
Background:
- Germ cell tumors with somatic-type malignancy (GCTSTM) are rare and associated with extremely poor prognoses.
- Somatic-type malignancies, often sarcomas, typically exhibit chemoresistance, complicating treatment strategies.
Purpose of the Study:
- To report a rare case of a durable response to Pazopanib in a patient with GCTSTM.
- To highlight Pazopanib as a potential therapeutic option for GCTSTM.
Main Methods:
- A case study of a 21-year-old male patient with GCTSTM following chemotherapy for a primary mediastinal germ cell tumor.
- Administration of Pazopanib, a multityrosine kinase inhibitor, for two years.
Main Results:
- The patient achieved disease stability despite multiple lung metastases.
- The patient maintained stability for four years after discontinuing Pazopanib.
Conclusions:
- This case represents the first reported durable response to Pazopanib in GCTSTM.
- Pazopanib may offer a novel therapeutic strategy for managing GCTSTM, a condition with limited treatment options.
Keywords:
Pazopanibchemoresistancechemotherapygerm cell tumorgerm cell tumor with somatic-type malignancy
