Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Gene Therapy

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Does Gamma Knife Stereotactic Radiosurgery Preserve Hearing on Short- and Long-Term Follow-Up?

The Laryngoscope·2026

Same author

Otological conditions and autism spectrum disorder in Medicaid beneficiaries aged 1 to 20 years: a cross-sectional study.

BMC pediatrics·2026

Same author

Processing-Driven Control of the Properties of Polymer Grafted Nanoparticle Composites.

ACS nano·2026

Same author

Multi-Task Assessment of Context-Specific Gait Changes to Virtual Reality-Based Visual Perturbations.

The Laryngoscope·2026

Same author

Reply: comment on "Superior semicircular abnormalities are more common in patients presenting to the emergency room with unexplained vertigo".

Clinical imaging·2026

Same author

Parameterized shape optimization of a bi-leaflet heart valved conduit for pediatric applications.

Engineering with computers·2026

Same journal

Auditory Brainstem Response in Autistic Children: Implications for Sensory Processing.

Hearing, balance and communication·2024

Same journal

The development of auditory temporal processing during the first year of life.

Hearing, balance and communication·2022

Same journal

Considering the impact of Universal Newborn Hearing Screening and early intervention on language outcomes for children with congenital hearing loss.

Hearing, balance and communication·2021

Same journal

The Effects of Stimulus Rate on ABR Morphology and its Relationship to P1 CAEP Responses and Auditory Speech Perception Outcomes in Children with Auditory Neuropathy Spectrum Disorder: Evidence from Case Reports.

Hearing, balance and communication·2020

Same journal

Hidden Age-Related Hearing Loss and Hearing Disorders: Current Knowledge and Future Directions.

Hearing, balance and communication·2019

Same journal

Genetic screening revealed usher syndrome in a paediatric Chinese patient.

Hearing, balance and communication·2019

See all related articles

Search research articles

Related Experiment Video

Updated: Nov 17, 2025

Posterior Semicircular Canal Approach for Inner Ear Gene Delivery in Neonatal Mouse

Posterior Semicircular Canal Approach for Inner Ear Gene Delivery in Neonatal Mouse

Published on: March 2, 2018

Inner Ear Gene Delivery: Vectors and Routes.

Chris Valentini¹, Betsy Szeto¹, Jeffrey W Kysar^1,2

¹Department of Otolaryngology -- Head and Neck Surgery, Columbia University Vagelos College of Physicians and Surgeons, New York, NY.

Hearing, Balance and Communication

|February 19, 2021

Summary

This summary is machine-generated.

Gene therapy offers a promising approach to restore hearing by addressing underlying defects. Advances in viral and non-viral vectors, along with inner ear delivery methods, are key to overcoming challenges in treating hearing loss.

Keywords:

Gene therapy hearing loss inner ear delivery non-viral vector viral vector

More Related Videos

Surgical Method for Virally Mediated Gene Delivery to the Mouse Inner Ear through the Round Window Membrane

Surgical Method for Virally Mediated Gene Delivery to the Mouse Inner Ear through the Round Window Membrane

Published on: March 16, 2015

Gene Transfer to the Developing Mouse Inner Ear by In Vivo Electroporation

Gene Transfer to the Developing Mouse Inner Ear by In Vivo Electroporation

Published on: June 30, 2012

Related Experiment Videos

Last Updated: Nov 17, 2025

Posterior Semicircular Canal Approach for Inner Ear Gene Delivery in Neonatal Mouse

Posterior Semicircular Canal Approach for Inner Ear Gene Delivery in Neonatal Mouse

Published on: March 2, 2018

Surgical Method for Virally Mediated Gene Delivery to the Mouse Inner Ear through the Round Window Membrane

Surgical Method for Virally Mediated Gene Delivery to the Mouse Inner Ear through the Round Window Membrane

Published on: March 16, 2015

Gene Transfer to the Developing Mouse Inner Ear by In Vivo Electroporation

Gene Transfer to the Developing Mouse Inner Ear by In Vivo Electroporation

Published on: June 30, 2012

Area of Science:

Otolaryngology
Ophthalmology
Molecular Biology

Background:

Current hearing loss treatments provide limited functional improvement.
Restoring normal hearing remains an unmet clinical need.
Gene therapy presents a potential solution for innate hearing defects.

Purpose of the Study:

Review recent advancements in viral and non-viral vectors for gene therapy.
Discuss strategies to overcome inner ear delivery barriers for gene products.
Highlight the potential of gene therapy for hearing restoration.

Main Methods:

Comprehensive literature search of Medline, EMBASE, Web of Science, and Google Scholar.
Utilized specific search terms related to inner ear anatomy and gene therapy.
Included reference lists of identified articles for study selection.

Main Results:

Both viral and non-viral vectors are crucial for advancing inner ear gene delivery.
The round window membrane presents a significant barrier to gene delivery.
Intratympanic and intracochlear delivery methods aim to overcome these barriers.

Conclusions:

Gene therapy holds promise for restoring hearing by correcting genetic defects.
Technological progress in inner ear drug delivery enhances gene therapy prospects.
Further research into delivery techniques is essential for successful gene therapy applications.