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Chronic Active Hepatitis B with COVID-19 in Pregnancy: A Case Report
Qiu-Yu Li1, Zhuo-Yu An2, Chao Li3
1Department of Respiratory and Critical Care Medicine, Peking University Third Hospital, Beijing, China.
Insights
Pregnant women with chronic active hepatitis B face risks when infected with COVID-19. This case report details successful treatment using liver support, antivirals, and dexamethasone for a critically ill patient.
Area of Science:
- Hepatology
- Infectious Diseases
- Maternal-Fetal Medicine
Background:
- Pregnancy increases susceptibility to severe outcomes from infections like COVID-19.
- Chronic active hepatitis B (CAH-B) is a significant underlying condition that can complicate viral infections during gestation.
Observation:
- A 31-year-old pregnant woman at 29 weeks gestation, with a history of chronic hepatitis B virus infection, presented with acute exacerbation of CAH-B after discontinuing antiviral therapy.
- She concurrently tested positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus causing COVID-19.
Findings:
- The patient received a combination of liver-protective agents, antiviral medications, and low-dose dexamethasone therapy.
- This multimodal treatment approach led to the successful management of her critical condition.
Implications:
- This case highlights the complex interplay between COVID-19 and chronic active hepatitis B in pregnancy.
- It demonstrates the potential efficacy of a targeted therapeutic strategy in managing critically ill pregnant patients with co-infections.
- Further research into managing co-infected pregnant populations is warranted.
Abstract:
Currently, infection with coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), during pregnancy is a problem worthy of attention, especially in patients with underlying diseases. In this case report, we present a case of chronic active hepatitis B with COVID-19 in pregnancy. A 31-year-old woman at 29 weeks of gestation who had a history of chronic hepatitis B virus infection discontinued antiviral treatment, was admitted to the hospital with chronic active hepatitis B, and tested positive for SARS-CoV-2 infection. In this case, we applied liver protective and antiviral agents, and low-dose dexamethasone therapy to successfully treat the critically ill pregnant woman suffering from chronic active hepatitis B combined with COVID-19.
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