MR-Guided Radiotherapy: The Perfect Partner for Immunotherapy?

Area of Science:

• Oncology
• Radiation Oncology
• Immunotherapy

Background:

• Preclinical and clinical studies support combining radiotherapy and immunotherapy.
• Radiotherapy can enhance immunotherapy by improving tumor antigen release, presentation, and T-cell infiltration.
• Magnetic resonance-guided radiotherapy (MRgRT) offers daily adaptive treatment planning.

Purpose of the Study:

• To review the potential of combining MR-guided adaptive radiotherapy with immunotherapy.
• To provide an overview of MRgRT status and radio-immunotherapy developments.
• To discuss opportunities and challenges in MR-guided radio-immunotherapy.

Main Methods:

• Review of current literature on MRgRT and radio-immunotherapy.
• Analysis of preclinical and clinical study findings.
• Discussion of unique aspects of MR-guided adaptive radiotherapy in combination with immunotherapy.

Main Results:

• MRgRT allows for daily on-table treatment adaptation.
• This adaptation enables dose escalation and improved sparing of organs-at-risk.
• MRgRT may help answer key questions in radio-immunotherapy.

Conclusions:

• MR-guided adaptive radiotherapy holds significant potential for enhancing immunotherapy efficacy.
• It offers precise tumor targeting and toxicity reduction.
• Further research is needed to optimize MR-guided radio-immunotherapy strategies.