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Related Experiment Video

Updated: Nov 16, 2025

The In ovo CAM-assay as a Xenograft Model for Sarcoma

The In ovo CAM-assay as a Xenograft Model for Sarcoma

Published on: July 17, 2013

Characteristics and Long-Term Risk of Breast Angiosarcoma.

Ann-Kristin U Friedrich¹, Emily S Reisenbichler², Danielle R Heller¹

¹Department of Surgery, Yale University School of Medicine, New Haven, CT, 06520, USA.

Annals of Surgical Oncology

|February 19, 2021

Summary

This summary is machine-generated.

Secondary breast angiosarcoma is more common and aggressive than primary. Risk factors include White race, older age, and prior breast cancer treatments like radiation and surgery.

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Area of Science:

Oncology
Cancer Epidemiology

Background:

Angiosarcoma of the breast is a rare and aggressive malignancy.
It can arise de novo or secondary to prior breast cancer treatment.

Purpose of the Study:

To compare primary and secondary breast angiosarcoma patient characteristics.
To identify risk factors associated with secondary angiosarcoma development.

Main Methods:

Utilized the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) database.
Analyzed population-based incidence of angiosarcoma in the breast, trunk, shoulder, and upper arm.
Compared primary and secondary angiosarcoma cases and breast cancer patient characteristics.

Main Results:

Secondary angiosarcomas constituted 65.4% of cases and were associated with worse survival.
Patients with secondary angiosarcoma were older, more likely White, and had higher-grade tumors.
Identified risk factors for secondary angiosarcoma include White race, older age, invasive tumor, lymph node removal, lumpectomy, radiation, and left-sided tumors.

Conclusions:

Angiosarcoma incidence is increasing, with secondary forms being more prevalent and aggressive.
Identified specific risk factors aid in counseling and identifying at-risk patients post-breast cancer treatment.
The risk for secondary angiosarcoma persists for up to 30 years after initial breast cancer treatment.