Related Experiment Video
Updated: Nov 16, 2025
08:35
Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion
Published on: May 26, 2022
3.7K
Association of Serum Aldosterone and Plasma Renin Activity With Ambulatory Blood Pressure in African Americans: The
Joshua J Joseph1, Neal K Pohlman1, Songzhu Zhao1
1The Ohio State University College of Medicine, Columbus (J.J.J., N.K.P., S.Z., D.K., G.B., B.K., W.A.H.).
Circulation
|February 19, 2021
Summary
Lower plasma renin activity (PRA) and higher aldosterone levels are linked to increased blood pressure (BP) in African Americans. Targeting low renin activity may improve hypertension control in this population.
Area of Science:
- Cardiovascular Medicine
- Endocrinology
- Hypertension Research
Background:
- The renin-angiotensin-aldosterone system (RAAS) significantly influences blood pressure (BP).
- Associations between RAAS components and ambulatory BP (ABP) phenotypes in African Americans remain understudied.
Purpose of the Study:
- To investigate the relationship between aldosterone, plasma renin activity (PRA), and ABP monitoring phenotypes in African Americans.
- To identify potential therapeutic targets for hypertension management in this demographic.
Main Methods:
- Utilized data from 912 Jackson Heart Study participants.
- Employed multivariable regression analyses to examine associations between aldosterone, PRA, and clinic/ambulatory BP, including hypertension phenotypes.
- Adjusted for key confounding factors.
Main Results:
- Lower PRA correlated with higher systolic and diastolic BP (DBP) during clinic, awake, and asleep periods.
- Higher aldosterone levels were associated with increased DBP.
- Reduced PRA was linked to lower odds of various hypertension types, including masked and sustained hypertension.
Conclusions:
- Suppressed renin activity and elevated aldosterone are associated with higher BP in African Americans.
- Higher aldosterone levels correlate with increased DBP.
- Further research into RAAS-targeting therapies is crucial for improving hypertension control in African Americans.
Keywords:
African Americansaldosteroneblood pressure monitoring, ambulatoryhypertensionlongitudinal studiesMore Related Videos
Related Concept Videos
01:25Antihypertensive Drugs: Direct Renin Inhibitors
1.0K
The renin-angiotensin-aldosterone system (RAAS) is an intricate physiological pathway involving numerous enzymes and hormones, including renin, angiotensin-converting enzyme (ACE), angiotensin I and II, and aldosterone. Imbalances within this system increase the production of angiotensin II and aldosterone. Increased angiotensin II levels promote vasoconstriction and blood pressure elevation. Concurrently, higher aldosterone levels stimulate sodium and water reabsorption in the kidneys,...
1.0K
01:30Antihypertensive Drugs: Angiotensin-Converting Enzyme Inhibitors
2.0K
Angiotensin-converting enzyme (ACE), a vital component of the renin-angiotensin-aldosterone system, is abundant in lung endothelial cells. ACE converts the inactive decapeptide, angiotensin I, into the active octapeptide, angiotensin II. This potent vasoconstrictor narrows blood vessels, increasing resistance to blood flow and elevating blood pressure. Angiotensin II also stimulates aldosterone production, encouraging kidney cells to reabsorb more sodium and water from urine, thereby increasing...
2.0K
01:33Hormonal Regulation
35.0K
The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.
35.0K
01:18Hypertension and Regulation of Blood Pressure
3.5K
Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
3.5K
01:30Antihypertensive Drugs: Angiotensin II Receptor Blockers
2.0K
In the renin-angiotensin-aldosterone system, a hormone called angiotensin II plays a crucial role. It binds to the AT1 receptors in vascular smooth muscles coupled with Gq proteins. The activation of these receptors activates an enzyme called phospholipase C, which releases two molecules: inositol trisphosphate and diacylglycerol. These molecules cause a chain reaction that leads to the phosphorylation of myosin light chains and promotes interaction between actin and myosin, leading to smooth...
2.0K
01:30Hypertension III: Clinical Manifestations and Diagnostic Studies
191
Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
191