Related Experiment Video

Updated: Nov 16, 2025

Development of Compendium for Esophageal Squamous Cell Carcinoma
03:36

Development of Compendium for Esophageal Squamous Cell Carcinoma

Published on: April 12, 2024

652

Involvement of long non-coding RNAs in the progression of esophageal cancer

Wenhua Xue1,2, Yuanyuan Zheng1,3, Zhibo Shen1,4,3

  • 1Department of Pharmacy, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, P. R. China.

Cancer Communications (London, England)
|February 19, 2021
PubMed

Insights

Long non-coding RNAs (lncRNAs) are key players in esophageal cancer (EC) development. This review explores how lncRNAs influence EC progression, offering insights into potential targeted therapies for this deadly disease.

Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • Esophageal cancer (EC) presents a significant global health challenge due to its high incidence and mortality.
  • Understanding EC pathogenesis and identifying novel targeted therapies are critical research priorities.
  • Long non-coding RNAs (lncRNAs) are increasingly recognized for their roles in various diseases, including cancer.

Purpose of the Study:

  • To review and discuss the involvement of lncRNAs in the progression of esophageal cancer.
  • To highlight the functional roles of lncRNAs in EC pathogenesis.
  • To explore the potential of lncRNAs as therapeutic targets for EC.

Main Methods:

  • Literature review of studies investigating lncRNAs in esophageal cancer.
  • Analysis of lncRNA expression patterns in EC tissues.
  • Examination of the molecular mechanisms by which lncRNAs regulate EC progression.

Main Results:

  • Abnormal expression of numerous lncRNAs is observed in EC.
  • lncRNAs participate in key biological processes such as cell proliferation, apoptosis, and metastasis in EC.
  • lncRNAs regulate EC progression via mechanisms including epithelial-mesenchymal transition (EMT).

Conclusions:

  • lncRNAs are significantly implicated in the pathogenesis and progression of esophageal cancer.
  • Dysregulated lncRNAs offer promising avenues for developing targeted therapies for EC.
  • Further research into lncRNA functions is crucial for advancing EC treatment strategies.
Keywords:
apoptosisbiomarkerdiagnosisdrug resistanceesophageal cancerlong non-coding RNAmetastasisprognosisproliferation

More Related Videos

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells07:23

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

Published on: May 30, 2025

854
Establishment and Histological Analysis of Esophageal Organoids Modeling the Progression from Normal to Cancerous Tissues05:57

Establishment and Histological Analysis of Esophageal Organoids Modeling the Progression from Normal to Cancerous Tissues

Published on: May 30, 2025

715

Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
9.4K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

3.1K
Non-LTR Retrotransposons03:18

Non-LTR Retrotransposons

As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
12.6K
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
5.8K
Esophageal Strictures-I: Introduction01:30

Esophageal Strictures-I: Introduction

Esophageal strictures involve abnormal narrowing or tightening of the esophagus. They vary in length and severity, ranging from mild constriction to complete obstruction, and are classified as benign (noncancerous) or malignant (cancerous).
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
380
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.4K