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Is idiopathic mild hyperprolactinemia a cardiovascular risk factor?
A O Koca1, M Dagdeviren1, T Akkan1
1Department of Endocrinology and Metabolism, Keçiören Training and Research Hospital, University of Health Sciences, Ankara, Turkey.
Nigerian Journal of Clinical Practice
|February 19, 2021
Summary
Arterial stiffness did not increase in young patients with mild hyperprolactinemia. Further research is needed to understand the long-term cardiovascular risks associated with elevated prolactin levels.
Area of Science:
- Endocrinology
- Cardiovascular Medicine
- Hypertension Research
Background:
- Arterial stiffness and endothelial dysfunction are linked to hypertension.
- The impact of elevated prolactin (PRL) on arterial stiffness is not well understood.
- Prolactin's role in atherosclerosis is an emerging area of research.
Purpose of the Study:
- To investigate cardiovascular risk prediction in idiopathic hyperprolactinemia.
- To assess arterial stiffness in patients with elevated prolactin levels.
Main Methods:
- Compared arterial stiffness and biochemical parameters in 54 patients with idiopathic hyperprolactinemia and 55 healthy controls.
- Utilized pulse wave velocity (PWV) measurements.
- Analyzed data from patients and controls with similar age, sex, and BMI.
Main Results:
- Median prolactin level in patients was 45 ng/mL (age 31).
- No significant differences in peripheral or central blood pressure or PWV were observed between groups.
- No correlation found between prolactin levels and blood pressure or arterial stiffness.
Conclusions:
- Arterial stiffness is not elevated in young patients with idiopathic mild hyperprolactinemia.
- Long-term cardiovascular effects of mildly elevated prolactin require further investigation.
- Prospective studies are needed to clarify the prolactin-cardiovascular risk relationship.
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