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Hyaline Inclusion Acanthoma.

Tien Anh N Tran¹, Ourania Parra², Konstantinos Linos^2,3

¹Department of Pathology, Advent Health Orlando, FL.

The American Journal of Dermatopathology

|February 19, 2021

Summary

This summary is machine-generated.

This study introduces hyaline inclusion acanthoma, a novel cutaneous lesion characterized by eosinophilic hyaline inclusions within squamous cells. This finding expands the understanding of keratinocyte pathology and potential diagnostic markers.

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Area of Science:

Dermatopathology
Oncology
Cell Biology

Background:

Eosinophilic hyaline inclusions (EHIs) are observed in various skin tumors, often linked to myoepithelial differentiation in basal cell carcinoma.
EHIs have not been definitively documented in genuine squamous cell lineage lesions without aberrant differentiation.

Observation:

A unique intraepidermal squamous lesion on a 71-year-old male's thigh showed enlarged keratinocytes with distinct intracytoplasmic EHIs.
The lesion lacked cytologic atypia, mitotic activity, and inflammatory cells, with EHIs staining positive for cytokeratins but negative for myoepithelial markers.

Findings:

The proposed "hyaline inclusion acanthoma" presents a novel histopathological entity.
Immunohistochemistry revealed strong diffuse positivity for cytokeratins, with differential staining by cytokeratin AE1 in suprabasal cells.
Negative results for human papillomavirus and common mutations in seborrheic or lichenoid keratoses ruled out other etiologies.

Implications:

This case expands the spectrum of cutaneous lesions featuring eosinophilic hyaline inclusions.
The distinct cytokeratin profile suggests a unique differentiation pathway within squamous lesions.
The proposed term "hyaline inclusion acanthoma" provides a specific designation for this rare finding.