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To Push or To Pull? In a Post-COVID World, Supporting and Incentivizing Antimicrobial Drug Development Must Become a

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Antimicrobial resistance poses a severe global threat, yet drug development is hampered by economic challenges. Governments must implement "pull" incentives to stimulate new antimicrobial development and ensure global health security.

Keywords:
One Healthaccessantimicrobial resistanceglobal health policymarket failurepush and pull incentives

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Area of Science:

  • Infectious Diseases
  • Global Health Economics
  • Pharmaceutical Policy

Background:

  • The COVID-19 pandemic highlighted global vulnerabilities to infectious diseases and economic impacts.
  • Antimicrobial resistance (AMR) presents a significant, yet under-appreciated, long-term threat to global health.
  • Existing health systems in high-income countries were strained by the recent pandemic, indicating broader systemic weaknesses.

Purpose of the Study:

  • To analyze current incentive strategies for antimicrobial drug development.
  • To evaluate the effectiveness of "push" versus "pull" incentives in addressing market failures.
  • To emphasize the need for economic solutions to revive the antimicrobial development pipeline.

Main Methods:

  • Review and analysis of existing antimicrobial incentive strategies.
  • Focus on "pull" incentives designed to improve market revenue for new antimicrobials.
  • Integration of a "One Health" perspective, considering broader ecological and societal factors.

Main Results:

  • "Push" incentives, while addressing R&D costs, have been insufficient to revive antimicrobial development pipelines.
  • "Pull" incentives, aimed at enhancing market revenue, are crucial for resolving the economic challenges in antimicrobial development.
  • The current economic model has led to a collapse in the development of new antimicrobial drugs.

Conclusions:

  • There is a critical need for governments to implement effective "pull" incentives to stimulate antimicrobial research and development.
  • Strict protocols for manufacturing and responsible use, within a "One Health" framework, are essential.
  • Sustained international cooperation, coordinated research efforts, and consistent funding are vital to combat antimicrobial resistance and secure future global health.