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Five new quinolizidine alkaloids, cylicomorphins A-E, were identified in Cylicomorpha solmstii leaves. Compound 5 showed significant cytotoxicity against HCT-116 cancer cells.

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Area of Science:

  • Natural Product Chemistry
  • Phytochemistry
  • Medicinal Chemistry

Background:

  • Cylicomorpha solmstii (Caricaceae) is a plant species.
  • Quinolizidine alkaloids represent a class of nitrogen-containing natural products.

Purpose of the Study:

  • To isolate and characterize new quinolizidine alkaloids from Cylicomorpha solmstii.
  • To evaluate the cytotoxic potential of the isolated compounds.

Main Methods:

  • Isolation of alkaloids using chromatographic techniques.
  • Structure elucidation via Nuclear Magnetic Resonance (NMR) spectroscopy.
  • Determination of absolute configuration using Vibrational Circular Dichroism (VCD) and Mosher ester derivatization.

Main Results:

  • Five novel quinolizidine alkaloids, named cylicomorphins A-E (1-5), were successfully isolated.
  • All compounds are ester derivatives of a common quinolizidine skeleton with specific substituents.
  • Compound 5 exhibited cytotoxicity against the HCT-116 cell line at a concentration of 10 μM.

Conclusions:

  • The study successfully identified and characterized five new quinolizidine alkaloids.
  • Cylicomorphin 5 demonstrates promising cytotoxic activity, warranting further investigation for potential therapeutic applications.