Related Experiment Video
Updated: Nov 16, 2025
09:36
Author Spotlight: Discovering New Alkaloids in Plants with Advanced Mass Spectrometry Techniques
Published on: March 8, 2024
1.2K
Quinolizidine Alkaloids from Cylicomorpha solmsii
Isabelle Pouny1, Christophe Long1, Muriel Batut1
1USR CNRS-Pierre Fabre No. 3388 ETaC, Centre de Recherche et Développement Pierre Fabre, 31035 Toulouse, France.
Journal of Natural Products
|February 19, 2021
Summary
Five new quinolizidine alkaloids, cylicomorphins A-E, were identified in Cylicomorpha solmstii leaves. Compound 5 showed significant cytotoxicity against HCT-116 cancer cells.
Area of Science:
- Natural Product Chemistry
- Phytochemistry
- Medicinal Chemistry
Background:
- Cylicomorpha solmstii (Caricaceae) is a plant species.
- Quinolizidine alkaloids represent a class of nitrogen-containing natural products.
Purpose of the Study:
- To isolate and characterize new quinolizidine alkaloids from Cylicomorpha solmstii.
- To evaluate the cytotoxic potential of the isolated compounds.
Main Methods:
- Isolation of alkaloids using chromatographic techniques.
- Structure elucidation via Nuclear Magnetic Resonance (NMR) spectroscopy.
- Determination of absolute configuration using Vibrational Circular Dichroism (VCD) and Mosher ester derivatization.
Main Results:
- Five novel quinolizidine alkaloids, named cylicomorphins A-E (1-5), were successfully isolated.
- All compounds are ester derivatives of a common quinolizidine skeleton with specific substituents.
- Compound 5 exhibited cytotoxicity against the HCT-116 cell line at a concentration of 10 μM.
Conclusions:
- The study successfully identified and characterized five new quinolizidine alkaloids.
- Cylicomorphin 5 demonstrates promising cytotoxic activity, warranting further investigation for potential therapeutic applications.
More Related Videos
Related Concept Videos
01:10Drugs that Destabilize Microtubules
2.2K
Microtubules are dynamic structures and can be regulated by microtubule targeting agents (MTAs). Microtubule destabilizing drugs are a class of MTAs that destabilize and prevent microtubules' polymerization. Both natural and synthetic chemicals can be found under this class of drugs. Vincristine and vinblastine, two vinca alkaloids, and colchicine were among the first to be discovered. These drugs can affect cells in various ways, either by inducing a change in cell morphology, preventing...
2.2K
01:15Drugs that Stabilize Microtubules
2.3K
Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the spindle apparatus for segregating the chromosomes. This makes them ideal targets for regulating dividing cells in tumors and malignant cancer cells. Microtubule stabilizing drugs help stabilize the microtubule formation and promote its polymerization. Paclitaxel was the first microtubule stabilizing agent used as anticancer drug in chemotherapy...
2.3K
01:11Aryldiazonium Salts to Azo Dyes: Diazo Coupling
3.3K
The reaction of weakly electrophilic aryldiazonium (also called arenediazonium) salts with highly activated aromatic compounds leads to the formation of products with an —N=N— link, called an azo linkage. This reaction, presented in Figure 1, is known as diazo coupling and occurs without the loss of the nitrogen atoms of the aryldiazonium salt. Highly activated aromatic compounds such as phenols or arylamines favor the diazo coupling reaction. The coupling generally occurs at the para...
3.3K