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Development of the Nude Rabbit Model.

Jun Song1, Mark Hoenerhoff2, Dongshan Yang1

  • 1Center for Advanced Models and Translational Sciences and Therapeutics, University of Michigan, Ann Arbor, MI 48109, USA.

Stem Cell Reports
|February 19, 2021
PubMed
Summary
This summary is machine-generated.

Researchers developed nude rabbits (NuRabbits) using CRISPR-Cas9 gene editing. These hairless, immunodeficient rabbits serve as valuable models for xenotransplantation and regenerative medicine research.

Keywords:
FOXN1immunodeficiencynude rabbitstem cellxenotransplant

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Area of Science:

  • Immunology
  • Genetics
  • Regenerative Medicine

Background:

  • Loss-of-function mutations in the forkhead box N1 (FOXN1) gene cause nude severe combined immunodeficiency.
  • This syndrome is characterized by athymia, T-cell immunodeficiency, alopecia, and nail dystrophy.

Purpose of the Study:

  • To report the establishment and maintenance of a colony of FOXN1 mutant nude rabbits (NuRabbits).
  • To demonstrate the utility of NuRabbits as a novel animal model for biomedical research.

Main Methods:

  • CRISPR-Cas9 gene editing was employed to produce FOXN1 mutant rabbits.
  • The establishment and maintenance of the NuRabbit colony were detailed.
  • Functional applications were assessed through xenotransplantation experiments.

Main Results:

  • NuRabbits were successfully generated and established as a colony.
  • These rabbits exhibit hairlessness, lack of thymic development, and immunodeficiency, similar to nude mice.
  • NuRabbits demonstrated successful engraftment as recipients in xenotransplantation with human induced pluripotent stem cells and tissue-engineered blood vessels.

Conclusions:

  • The NuRabbit represents a new immunodeficient animal model.
  • Its larger size and longer lifespan compared to nude mice offer unique advantages for research.
  • NuRabbits are suitable for applications in regenerative medicine, cancer research, and studying human immunodeficiency.