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Updated: Nov 16, 2025

Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells
Published on: February 21, 2014
miRNAs: Critical mediators of breast cancer metastatic programming
Madhumathy G Nair1, Vidya M Somashekaraiah1, Vishakha Ramamurthy1
1Division of Molecular Medicine, St. John's Research Institute, Bangalore, India.
Abstract:
MicroRNA mediated aberrant gene regulation has been implicated in several diseases including cancer. Recent research has highlighted the role of epigenetic modulation of the complex process of breast cancer metastasis by miRNAs. miRNAs play a crucial role in the process of metastatic evolution by facilitating alterations in the phenotype of tumor cells and the tumor microenvironment that promote this process. They act as critical determinants of the multi-step progression starting from carcinogenesis all the way to organotropism. In this review, we focus on the current understanding of the compelling role of miRNAs in breast cancer metastasis.
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