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Related Concept Videos

Longitudinal Research02:20

Longitudinal Research

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Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
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A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
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Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
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Updated: Nov 16, 2025

Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses
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SARS CoV2 infection _The longevity study perspectives.

Domenico Lio1, Letizia Scola2, Rosa Maria Giarratana3

  • 1Immunosenescence Study Group, Department of Biomedicine, Neuroscience and Advanced, Diagnostics (Bi.N.D.), University of Palermo, Palermo, Italy.

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|February 19, 2021
PubMed
Summary
This summary is machine-generated.

Certain elderly individuals exhibit remarkable COVID-19 resistance due to genetic factors. Studying these nonagenarians and centenarians may reveal protective genetic profiles for developing new COVID-19 therapies.

Keywords:
COVID-19Italian nonagenarians/centenariansLongevity modelResearching genetic basis of resistance and potential pharmacological targets

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Area of Science:

  • Immunology
  • Genetics
  • Infectious Diseases

Background:

  • COVID-19 presents variable clinical outcomes, from asymptomatic to lethal.
  • Older males with comorbidities are most susceptible, facing higher mortality and complications like respiratory distress.
  • Some Italian nonagenarians/centenarians display surprising resistance to COVID-19, recovering despite typical symptoms.

Purpose of the Study:

  • To investigate the genetic basis of COVID-19 resistance in exceptionally long-lived individuals.
  • To identify genetic profiles associated with COVID-19 susceptibility and protection.
  • To explore potential pharmacological targets for preventing or mitigating viral infections.

Main Methods:

  • Analysis of immune/inflammatory gene variants in long-lived individuals.
  • Comparative genetic profiling of COVID-19 resistant versus susceptible populations.
  • Correlation of genetic profiles with immune system performance and anti-inflammatory markers.

Main Results:

  • Long-lived individuals demonstrate optimal immune system performance.
  • Overexpression of anti-inflammatory variants in immune/inflammatory genes is observed in this group.
  • These genetic factors may contribute to their resistance against severe COVID-19 outcomes.

Conclusions:

  • Long-lived individuals serve as a valuable model for understanding COVID-19 resistance mechanisms.
  • Identifying protective genetic profiles can inform the development of novel therapeutic strategies.
  • Targeting these genetic factors could offer new avenues for preventing and treating COVID-19 in vulnerable populations.