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Assessing Stem Cell DNA Integrity for Cardiac Cell Therapy
Published on: January 25, 2019
Stem cell therapy in the heart: Biomaterials as a key route
Mohammad Reza Hashemzadeh1, Mohammad Ehsan Taghavizadeh Yazdi2, Mohammad Sadegh Amiri3
1Department of Stem Cells and Regenerative Medicine, Royesh Stem Cell Biotechnology Institute, Mashhad, Iran; Medical Toxicology Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Insights
Regenerative medicine for heart disease uses stem cells and biomaterials. This review explores natural products to enhance stem cell therapy for cardiovascular repair, addressing limitations of current treatments.
Area of Science:
- Cardiovascular Research
- Regenerative Medicine
- Biomaterials Science
Background:
- Cardiovascular diseases (CVDs) are a leading global cause of mortality.
- Conventional treatments primarily manage heart failure progression.
- Regenerative medicine offers novel cellular and noncellular therapeutic strategies for cardiac repair.
Purpose of the Study:
- To review the role of stem cells in cardiac regenerative therapy.
- To highlight the limitations of current stem cell delivery and integration methods.
- To evaluate natural products as supportive agents for stem cell-based cardiovascular regeneration.
Main Methods:
- Literature review of stem cell types (pluripotent and adult) for cardiac applications.
- Analysis of challenges in stem cell therapy, including tissue integration and retention.
- Exploration of biomaterials and natural products to overcome therapeutic obstacles.
Main Results:
- Noncellular approaches (exosomes, miRNAs, growth factors) have limitations in reversing myocardial damage.
- Stem cell therapy holds promise but faces hurdles like inefficient delivery and poor cell retention.
- Biomaterials and natural products are crucial for improving stem cell efficacy and integration in the cardiac environment.
Conclusions:
- Stem cell therapy is indispensable for reversing necrotic or ischemic myocardium.
- Biomaterials offer a key route to address challenges in cardiac repair and stem cell delivery.
- Natural products show potential to enhance stem cell function in cardiovascular regenerative medicine.
Abstract:
Cardiovascular diseases are one of the main concerns, nowadays causing a high rate of mortality in the world. The majority of conventional treatment protects the heart from failure progression. As a novel therapeutic way, Regenerative medicine in the heart includes cellular and noncellular approaches. Despite the irrefutable privileges of noncellular aspects such as administration of exosomes, utilizing of miRNAs, and growth factors, they cannot reverse necrotic or ischemic myocardium, hence recruiting of stem cells to help regenerative therapy in the heart seems indispensable. Stem cell lineages are varied and divided into two main groups namely pluripotent and adult stem cells. Not only has each of which own regenerative capacity, benefits, and drawbacks, but their turnover also close correlates with the target organ and/or tissue as well as the stage and level of failure. In addition to inefficient tissue integration due to the defects in delivering methods and poor retention of transplanted cells, the complexity of the heart and its movement also make more rigorous the repair process. Hence, utilizing biomaterials can make a key route to tackle such obstacles. In this review, we evaluate some natural products which can help stem cells in regenerative medicine of the cardiovascular system.
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