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A Fucoxanthinol Induces Apoptosis in a Pancreatic Intraepithelial Neoplasia Cell
Masaru Terasaki1,2, Takuya Inoue3, Wataru Murase3
1School of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Hokkaido, Japan; terasaki@hoku-iryo-u.ac.jp.
Background/Aim:
Fucoxanthinol (FxOH), a predominant metabolite from fucoxanthin (Fx), can exert potential anti-cancer effects in various cancers. However, limited data are available on the effect of FxOH or Fx on pancreatic cancer. The present study investigated the effect of FxOH on a cell line derived from pancreatic cancer tissue developed in Ptf1aCre/+; LSL-k-rasG12D/+ mice.
Materials And Methods:
Using flow-cytometric, microarrays, and western blotting analyses, alterations in FxOH-induced apoptosis-related gene expression and protein levels were evaluated in a mice pancreatic cancer cell line, KMPC44.
Results:
FxOH significantly arrested the cells at S phase along with suppression of many gene sets, such as cytokine- cytokine receptor interaction and cell adhesion molecule CAMS. Moreover, attenuated protein levels for cytokine receptors, adhesion, phosphatidylinositol-3 kinase/protein kinase B, and mitogen-activated protein kinase were observed.
Conclusion:
FxOH may prevent pancreatic cancer development in a murine cancer model.
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