Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Detailed Structure and Function of Lymph Nodes01:23

Detailed Structure and Function of Lymph Nodes

3.6K
Lymph nodes are bean-shaped structures that cluster along the lymphatic vessels in the inguinal, axillary, and cervical regions. Each node is divided into compartments by a capsule that extends trabeculae inward.
From a histological perspective, lymph nodes can be split into two main areas: the superficial cortex and the deep medulla. The outer cortex is populated by dendritic cells, macrophages, and B lymphocytes, which are densely packed into follicles. When these B-lymphocytes are presented...
3.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Association Between Number of Hospital Advanced Practice Providers and Surgical Morbidity.

Cancer medicine·2026
Same author

Perinephric myxoid pseudotumor of fat in kidney transplant recipients: A single-center experience and review of the literature.

Clinical nephrology·2026
Same author

Same Day Discharge After Prostatectomy for Prostate Cancer and Readmissions.

Cancer medicine·2026
Same author

Utility of Next-Generation Sequencing in Renal Neoplasia, Including Tumors With Clear Cytoplasm and Rare Phenotypes (ELOC/MITF Alterations and Mismatch Repair Deficiency).

Mayo Clinic proceedings·2026
Same author

Impact of In-Office Dispensing Adoption by Urology Practices on Oral Specialty Drug Use in Advanced Prostate Cancer.

Cancer medicine·2026
Same author

Twelve-Month Results From the CISTO Study Comparing Radical Cystectomy Versus Bladder-Sparing Therapy for Recurrent High-Grade Non-Muscle-Invasive Bladder Cancer.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology·2025

Related Experiment Video

Updated: Nov 16, 2025

Quantification of Tumor Cell Adhesion in Lymph Node Cryosections
06:09

Quantification of Tumor Cell Adhesion in Lymph Node Cryosections

Published on: February 9, 2020

12.7K

Variation in Lymph Node Yield After Radical Cystectomy.

Kassem S Faraj1, Nathanael Judge1, Yu-Hui H Chang2

  • 1Departments of Urology.

American Journal of Clinical Pathology
|February 20, 2021
PubMed
Summary
This summary is machine-generated.

Pathology assistant (PA) performance did not significantly impact lymph node yield in radical cystectomy (RC) patients. Lymph node counts varied by surgeon, pathologist, clinical stage, and dissection extent, not by PA.

Keywords:
Bladder cancerCystectomyLymphadenectomyProcessing

More Related Videos

Clinical Application of Single-Surgeon, Three-Port, Laparoscopic Resection for Colorectal Cancer with Natural Orifice Specimen Extraction
08:26

Clinical Application of Single-Surgeon, Three-Port, Laparoscopic Resection for Colorectal Cancer with Natural Orifice Specimen Extraction

Published on: March 24, 2023

946
Author Spotlight: A Model to Study the Systemic and Local Dynamics of CD8+ T Cells During LN Metastasis
07:45

Author Spotlight: A Model to Study the Systemic and Local Dynamics of CD8+ T Cells During LN Metastasis

Published on: January 26, 2024

2.3K

Related Experiment Videos

Last Updated: Nov 16, 2025

Quantification of Tumor Cell Adhesion in Lymph Node Cryosections
06:09

Quantification of Tumor Cell Adhesion in Lymph Node Cryosections

Published on: February 9, 2020

12.7K
Clinical Application of Single-Surgeon, Three-Port, Laparoscopic Resection for Colorectal Cancer with Natural Orifice Specimen Extraction
08:26

Clinical Application of Single-Surgeon, Three-Port, Laparoscopic Resection for Colorectal Cancer with Natural Orifice Specimen Extraction

Published on: March 24, 2023

946
Author Spotlight: A Model to Study the Systemic and Local Dynamics of CD8+ T Cells During LN Metastasis
07:45

Author Spotlight: A Model to Study the Systemic and Local Dynamics of CD8+ T Cells During LN Metastasis

Published on: January 26, 2024

2.3K

Area of Science:

  • Urology
  • Oncology
  • Pathology

Background:

  • Lymph node yield is a critical indicator of surgical quality in radical cystectomy (RC).
  • Variability in lymph node counts may be influenced by multiple factors, including personnel involved in specimen handling and analysis.

Purpose of the Study:

  • To investigate whether pathology assistant (PA) performance influences lymph node yield in patients undergoing radical cystectomy (RC) with pelvic lymph node dissection (PLND).

Main Methods:

  • Single-institution retrospective review of 430 patients undergoing RC with PLND for bladder cancer (2007-2018).
  • Multivariable regression analysis was used to predict mean lymph node counts.
  • Analysis considered factors including level of dissection, clinical stage, neoadjuvant chemotherapy, surgical approach, surgeon, pathologist, and PA.

Main Results:

  • The median lymph node count was 15.0 (IQR 11.0-21.0).
  • Descriptive analysis showed differences in lymph node yield based on dissection level, clinical stage, neoadjuvant chemotherapy, surgical approach, surgeon, pathologist, and PA (P < .05).
  • Multivariable analysis revealed adjusted lymph node counts varied by surgeon, pathologist, clinical stage, and dissection level, but not by PA (P = .18).

Conclusions:

  • Lymph node yield in RC is influenced by surgeon, extent of lymphadenectomy, clinical stage, and pathologist.
  • This study found no significant variation in lymph node yield attributable to the pathology assistant.