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Related Experiment Video

Updated: Nov 16, 2025

Reconstruction of 3-Dimensional Histology Volume and its Application to Study Mouse Mammary Glands

Reconstruction of 3-Dimensional Histology Volume and its Application to Study Mouse Mammary Glands

Published on: July 26, 2014

MR method for measuring microscopic histologic soft tissue textures.

Geoffrey A Sonn^1,2, Richard E Fan¹, Christian A Kunder³

¹Department of Urology, Stanford School of Medicine, Stanford, California, USA.

Magnetic Resonance in Medicine

|February 20, 2021

Summary

This summary is machine-generated.

This study introduces MR micro-Texture (MRµT), a novel MRI method for non-invasively measuring microscopic tissue texture. MRµT can differentiate normal from cancerous tissues, offering improved diagnostic capabilities for various diseases.

Keywords:

cancer histology magnetic resonance microMRI motion immunity prostate

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Last Updated: Nov 16, 2025

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Area of Science:

Biomedical Engineering
Medical Imaging
Materials Science

Background:

Standard MRI lacks the resolution to analyze microscopic tissue textures crucial for disease diagnosis.
A need exists for non-invasive methods to assess tissue at the micron scale, bridging the gap between histology and clinical imaging.

Purpose of the Study:

To develop and demonstrate a direct, non-invasive diagnostic measure of microscopic tissue texture.
To enable the measurement of pathologic tissue textures in the presence of subject motion within an MR scanner.

Main Methods:

MR micro-Texture (MRµT) utilizes targeted k-value measurements and selective excitation to analyze tissue texture.
A high k-value phase encode within an isolated region of interest (VOI) provides motion immunity.
Data acquisition involves single excitations per k-value, allowing extended acquisition for improved signal-to-noise ratio.

Main Results:

Demonstrated resolution below 50 µm, showcasing motion immunity.
Successfully differentiated between normal and cancerous tissue textures.
Revealed textural differences not detectable by standard MR imaging.

Conclusions:

MR micro-Texture (MRµT) provides a novel diagnostic tool for microscopic tissue analysis.
As an MR pulse sequence, MRµT is directly applicable to existing clinical MRI scanners.
This method holds potential for improving cancer imaging and diagnosis.