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Epigenetics of ankylosing spondylitis: Recent developments.

Hui Yang1,2, Yuting Chen1,2, Wei Xu1,2

  • 1Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, China.

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|February 20, 2021
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Summary

Ankylosing spondylitis (AS) pathogenesis involves genetic and environmental factors. Epigenetic modifications like DNA methylation and microRNAs play a crucial role in AS development and progression.

Keywords:
ankylosing spondylitisepigenetichistonemethylationmicroRNA

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Area of Science:

  • Immunology
  • Genetics
  • Epigenetics

Background:

  • Ankylosing spondylitis (AS) is a chronic inflammatory autoimmune disease affecting the spine and joints.
  • The exact causes and pathogenesis of AS remain largely unknown, with suspected links to genetic, environmental, and infectious factors.

Purpose of the Study:

  • To summarize recent advancements in understanding the epigenetics of ankylosing spondylitis.
  • To explore the role of epigenetic modifications in AS pathogenesis.

Main Methods:

  • Review of current literature on epigenetic modifications in AS.
  • Focus on DNA methylation, histone modification, and microRNA alterations in AS-associated genomic loci.

Main Results:

  • Abnormal epigenetic modifications are identified at genomic loci associated with AS.
  • Specific epigenetic mechanisms, including DNA methylation, histone modification, and microRNAs, are implicated in AS development.

Conclusions:

  • Epigenetic modifications are significant contributors to the occurrence and progression of ankylosing spondylitis.
  • Further research is needed to fully elucidate the complex epigenetic landscape of AS and its therapeutic implications.