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In Silico Clinical Trials for Cardiovascular Disease
Published on: May 27, 2022
The Use of Colchicine in Cardiovascular Diseases: A Systematic Review
Jessica Siak1, Nir Flint2, Hezzy G Shmueli2
1Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, Calif.
Abstract:
The medicinal properties of colchicine have been recognized for centuries. Although previously used for gout and familial Mediterranean fever, its immune-modulating, anti-inflammatory, and antifibrotic effects are increasingly recognized as beneficial in the treatment of cardiovascular disorders. In this systematic review, we summarize the current evidence on colchicine's effectiveness in 1) pericarditis, 2) coronary artery disease, and 3) atrial fibrillation. We also discuss the safety, potential adverse effects, and common drug interactions that should be considered during use.
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